BMP6 active protein

BMP6 protein

Cat. Num. AAA539568

• Gene Names: BMP6; VGR; VGR1
• Applications: User optimized
• Purity: > 95% pure
• Synonyms: BMP6; BMP6 protein; BMP 6 protein; VGR protein; Bone Morphogenetic protein 6 protein; BMP-6; BMP-6 protein; BMP 6; BMP6 active protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: Lyophilized from 10mM Tris, pH 9.0. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
• Sequence: Region of BMP6 protein corresponding to amino acids VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH.
• Sequence Length: 5

• Applicable Applications for BMP6 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: TGF beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown.
• Bioactivity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 ug/ml.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: HEK cells
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for BMP6 active protein

Purified recombinant Human BMP6 protein

Product Categories/Family for BMP6 active protein

Differentiation & Development

NCBI and Uniprot Product Information

• NCBI GI #: 3492993
• NCBI GeneID: 654
• UniProt Accession #: P22004; Q5TCP3
• Molecular Weight: 26.2 kDa
• NCBI Official Full Name: bone morphogenetic protein 6, partial
• NCBI Official Synonym Full Names: bone morphogenetic protein 6
• NCBI Official Symbol: BMP6
• NCBI Official Synonym Symbols: VGR; VGR1
• NCBI Protein Information: bone morphogenetic protein 6
• UniProt Protein Name: Bone morphogenetic protein 6
• Protein Family: Bone morphogenetic protein
• UniProt Gene Name: BMP6
• UniProt Synonym Gene Names: VGR; BMP-6; VG-1-R; VGR-1
• UniProt Entry Name: BMP6_HUMAN

NCBI Description

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

Uniprot Description

BMP6: Induces cartilage and bone formation. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p24-p23

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; protein heterodimerization activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: cellular iron ion homeostasis; response to glucocorticoid stimulus; BMP signaling pathway; regulation of apoptosis; response to magnesium ion; positive regulation of endothelial cell differentiation; positive regulation of aldosterone biosynthetic process; male genitalia development; kidney development; inflammatory response; response to iron ion; skeletal development; endochondral ossification; response to retinoic acid; positive regulation of bone mineralization; osteoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of chondrocyte differentiation; eye development; positive regulation of protein secretion; regulation of MAPKKK cascade; cartilage development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; immune response; response to activity; positive regulation of neuron differentiation; positive regulation of epithelial cell proliferation; growth