PF4 active protein
PF4 protein
Gene Names
PF4V1; PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1
Applications
User optimized
Purity
> 98% pure
Synonyms
PF4; PF4 protein; PF-4 protein; PF 4 protein; Oncostatin A protein; CXCL4 protein; PF 4; PF-4; Platelet Factor-4 protein; Ironplact protein; PF4 active protein
Host
Human
Purity/Purification
> 98% pure
Form/Format
Supplied as a lyophilized powder.
Sequence
Region of PF4 protein corresponding to amino acids EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES.
Sequence Length
104
Applicable Applications for PF4 active protein
User optimized
Protein Type
Recombinant
Biological Significance
PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the alpha-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.
Bioactivity
Determined by its ability to chemoattract human fibroblasts using a concentration range of 1.0-10.0 ng/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for PF4 active protein
Purified recombinant Human PF4 protein
Product Categories/Family for PF4 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
7.8 kDa
NCBI Official Full Name
platelet factor 4
NCBI Official Synonym Full Names
platelet factor 4 variant 1
NCBI Official Symbol
PF4V1
NCBI Official Synonym Symbols
PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1
NCBI Protein Information
platelet factor 4 variant
UniProt Protein Name
Platelet factor 4 variant
Protein Family
UniProt Gene Name
PF4V1
UniProt Synonym Gene Names
CXCL4V1; SCYB4V1
UniProt Entry Name
PF4V_HUMAN
Uniprot Description
PF4V1: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro). Belongs to the intercrine alpha (chemokine CxC) family.
Protein type: Chemokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q12-q21
Cellular Component: extracellular space
Molecular Function: heparin binding; chemokine activity; CXCR chemokine receptor binding
Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; immune response; inflammatory response; regulation of cell proliferation
Research Articles on PF4
Similar Products
Product Notes
The PF4 pf4v1 (Catalog #AAA539520) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PF4 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the PF4 pf4v1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of PF4 protein correspond ing to amino acids EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES. It is sometimes possible for the material contained within the vial of "PF4, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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