EBV EBNA recombinant protein
EBV EBNA protein
Applications
User optimized
Purity
> 99% pure
Synonyms
EBV EBNA; EBV EBNA protein; Epstein Barr Virus Nuclear Antigen protein; EBV-EBNA protein; EBV EBNA recombinant protein
Host
Viral
Purity/Purification
> 99% pure
Form/Format
Supplied as a liquid in PBS, pH 6.5.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
1009
Applicable Applications for EBV EBNA recombinant protein
User optimized
Protein Type
Recombinant
Biological Significance
The Epstein-Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is a virus of the herpes family, which includes herpes simplex virus 1 and 2, and is one of the most common viruses in humans. It is best known as the cause of infectious mononucleosis. It is also associated with particular forms of cancer, particularly Hodgkin's lymphoma, Burkitt's lymphoma, nasopharyngeal carcinoma, and central nervous system lymphomas associated with HIV. Epstein-Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein-Barr virus. It is the only viral protein of Epstein-Barr that is found in all EBV-related malignancies. It is important in establishing and maintaining the altered state that cells take when infected with EBV.
Expression System
E Coli
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store frozen at -20 degreeree C until reconstituted then store frozen at -70 degreeree C.
Related Product Information for EBV EBNA recombinant protein
Purified recombinant EBV EBNA protein
Product Categories/Family for EBV EBNA recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
112,164 Da
NCBI Official Full Name
Epstein-Barr nuclear antigen 6
UniProt Protein Name
Epstein-Barr nuclear antigen 6
UniProt Gene Name
EBNA6
UniProt Synonym Gene Names
EBNA-6; EBV nuclear antigen 6; EBNA-3C; EBV nuclear antigen 3C; EBNA-4B; EBV nuclear antigen 4B
UniProt Entry Name
EBNA6_EBVG
Uniprot Description
Plays an essential role for the activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA6 probably contributes to a negative autoregulatory control loop. Alternatively, EBNA6 also regulates the transcription of the EBV oncogene LMP1 in a cell cycle-dependent manner. Modulates the activity of several host proteins involved in cell cycle regulation including host cyclin A, MYC, RB, p21 and p27 mainly through binding to the host SCF(SKP2) complex. Inhibits the promoter of host H2AX and targets H2AX to proteasomal degradation in order to promote latency and cell proliferation.
Similar Products
Product Notes
The EBV EBNA ebna6 (Catalog #AAA538336) is a Recombinant Protein produced from Viral and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's EBV EBNA can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the EBV EBNA ebna6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EBV EBNA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
