IP10 active protein

IP10 protein

Cat. Num. AAA538288

• Gene Names: Cxcl10; C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: IP10; IP10 protein; IP-10 protein; gamma-Interferon Inducible Protein 10 protein; crg-2 protein; IP-10; CXCL10 protein; IP 10 protein; IP 10; IP10 active protein

• Host: Human
• Purity/Purification: > 98% pure
• Form/Format: Sterile filtered through a 0.2 um filter. Lyophilized with no additives.
• Sequence: Region of IP10 protein corresponding to amino acids VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK EMSKRSP.
• Sequence Length: 98

• Applicable Applications for IP10 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells.
• Bioactivity: Determined by its ability to chemoattract human T-lymphoytes using a concentration of 10-50 ng/ml.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for IP10 active protein

Purified recombinant Human IP10 protein

Product Categories/Family for IP10 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 976159
• NCBI GeneID: 15945
• UniProt Accession #: P17515
• Molecular Weight: 10,789 Da
• NCBI Official Full Name: IP-10
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 10
• NCBI Official Symbol: Cxcl10
• NCBI Official Synonym Symbols: C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10
• NCBI Protein Information: C-X-C motif chemokine 10
• UniProt Protein Name: C-X-C motif chemokine 10
• UniProt Gene Name: Cxcl10
• UniProt Synonym Gene Names: Crg2; Ifi10; Inp10; Scyb10; Gamma-IP10; IP-10
• UniProt Entry Name: CXL10_MOUSE

Uniprot Description

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Chemokine; Secreted, signal peptide

Cellular Component: extracellular space; cell; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of myoblast differentiation; inflammatory response; defense response to virus; positive regulation of cell migration