KGF active protein

KGF protein

Cat. Num. AAA538260

• Gene Names: FGF7; KGF; HBGF-7
• Applications: User optimized
• Purity: > 95% pure
• Synonyms: KGF; KGF protein; Keratinocyte Growth Factor protein; HBGF-7 protein; Fibroblast Growth Factor-7 protein; KGF active protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: Lyophilized from 15mM Na3PO4 with 0.25 M NaCl, pH7.0. Reconstitute in PBS to a concentration of 0.5-1.0 mg/ml.
• Sequence: Region of KGF protein corresponding to amino acids MCNDMTPEQM ATNVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT.
• Sequence Length: 194

• Applicable Applications for KGF active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: Keratinocyte Growth Factor (KGF/FGF7) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of variety of tissues, by promoting cellular proliferation and differentiation. KGF/FG-7 is a mitogen factor specific for epithelial cells and keratinocytes and signals through FGFR 2b. KGF/FGF7 plays a role in kidney and lung development, angiogenesis, and wound healing.
• Bioactivity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by KGF-responsive BaF3 cells is approximately 10 ng/ml, corresponding to a specific activity of approximately 1 x 10^5 units/mg.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for KGF active protein

Purified recombinant Human KGF protein

Product Categories/Family for KGF active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 245439
• NCBI GeneID: 2252
• UniProt Accession #: P21781; Q6FGV5; Q96FG5; H0YNY5
• Molecular Weight: 18.9 kDa
• NCBI Official Full Name: Keratinocyte growth factor
• NCBI Official Synonym Full Names: fibroblast growth factor 7
• NCBI Official Symbol: FGF7
• NCBI Official Synonym Symbols: KGF; HBGF-7
• NCBI Protein Information: fibroblast growth factor 7
• UniProt Protein Name: Fibroblast growth factor 7
• UniProt Gene Name: FGF7
• UniProt Synonym Gene Names: KGF; FGF-7; HBGF-7
• UniProt Entry Name: FGF7_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF7: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: Golgi apparatus; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; fibroblast growth factor receptor binding; chemoattractant activity

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; epidermis development; hair follicle morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; mesenchymal cell proliferation; signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; positive chemotaxis; positive regulation of cell division; positive regulation of cell proliferation; actin cytoskeleton reorganization; response to wounding; insulin receptor signaling pathway; innate immune response; positive regulation of epithelial cell proliferation