ApoC-I native protein

ApoC-I protein

Cat. Num. AAA537064

• Gene Names: APOC1; Apo-CI; ApoC-I
• Applications: User optimized
• Purity: > 95% pure
• Synonyms: ApoC-I; ApoC-I protein; Apo CI protein; ApoC1 protein; ApoC I protein; Apolipoprotein C-I protein; ApoC-I native protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: Lyophilized from 10mM NH4HCO3, pH 7.4.
• Sequence Length: 83

• Applicable Applications for ApoC-I native protein: User optimized
• Source Note: Human plasma
• Protein Type: Native
• Biological Significance: Apolipoprotein CI is one of the protein components of VLDL lipoprotein. The normal plasma concentration of Apo CI is 4-7 mg per 100 ml. Elevated levels of Apo CI may offer some protection from obesity and insulin-dependent diabetes. Some evidence exists that the Apo CI H2 gene is positively associated with late-onset Alzheimer's disease.
• Biohazard Information: Donor samples were tested and found to be negative for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
• Preparation and Storage: Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for ApoC-I native protein

Purified native Human ApoC-I protein

Product Categories/Family for ApoC-I native protein

Nutrition & Metabolism; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 757914
• NCBI GeneID: 341
• UniProt Accession #: P02654; Q6IB97; B2R526
• Molecular Weight: 6.6 kDa
• NCBI Official Full Name: apolipoprotein CI
• NCBI Official Synonym Full Names: apolipoprotein C-I
• NCBI Official Symbol: APOC1
• NCBI Official Synonym Symbols: Apo-CI; ApoC-I
• NCBI Protein Information: apolipoprotein C-I
• UniProt Protein Name: Apolipoprotein C-I
• UniProt Gene Name: APOC1
• UniProt Synonym Gene Names: Apo-CI; ApoC-I
• UniProt Entry Name: APOC1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

APOC1: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Belongs to the apolipoprotein C1 family.

Protein type: Inhibitor; Lipid-binding; Secreted, signal peptide; Endoplasmic reticulum; Secreted

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: chylomicron; endoplasmic reticulum

Molecular Function: phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding

Biological Process: positive regulation of catalytic activity; cholesterol metabolic process; negative regulation of cholesterol transport; lipoprotein metabolic process; cholesterol efflux; triacylglycerol metabolic process; phospholipid efflux; negative regulation of lipid catabolic process; negative regulation of receptor-mediated endocytosis; negative regulation of lipoprotein lipase activity; lipid metabolic process; negative regulation of lipid metabolic process; regulation of cholesterol transport; negative regulation of fatty acid biosynthetic process