Rabbit HIV1 protease Polyclonal Antibody
HIV1 protease antibody
Reactivity
Binds to recombinant Protease (HIV -1). Not tested for sterility or endotoxin content.
Applications
ELISA, Western Blot
Purity
> 95% pure
Synonyms
HIV1 protease; Polyclonal Antibody; HIV1 protease antibody; Polyclonal HIV1 protease; Anti-HIV1 protease; HIV 1 protease; HIV-1 protease; anti-HIV1 protease antibody
Host
Rabbit
Reactivity
Binds to recombinant Protease (HIV -1). Not tested for sterility or endotoxin content.
Clonality
Polyclonal
Isotype
IgG
Specificity
HIV -1 protease
Purity/Purification
> 95% pure
Form/Format
Supplied as a purified IgG in PBS buffer, >95% pure by SDS-PAGE analysis, with no preservatives added. Reconstitute with sterile distilled water.
Applicable Applications for anti-HIV1 protease antibody
ELISA (EIA), Western Blot (WB)
Application Notes
If protein concentration is 1mg/ml, suggested starting dilutions are:
ELISA and Western Blot 1:500-1:1,000
Optimal dilutions must be determined by end user.
ELISA and Western Blot 1:500-1:1,000
Optimal dilutions must be determined by end user.
Biological Significance
HIV-1 protease (HIV PR) is a retroviral aspartyl protease that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV PR cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. Without effective HIV PR, HIV virions remain uninfectious. Thus, mutation of HIV PR?s active site or inhibition of its activity disrupts HIV?s ability to replicate and infect additional cells, making HIV PR inhibition the subject of much pharmaceutical research.
Immunogen
Full length recombinant Protease (HIV-1) expressed in E.coli Expression System
Preparation and Storage
Upon receipt store at 4°C while lyophilized, -70°C once reconstituted.
Related Product Information for anti-HIV1 protease antibody
Rabbit polyclonal HIV1 protease antibody
Product Categories/Family for anti-HIV1 protease antibody
NCBI and Uniprot Product Information
UniProt Accession #
Uniprot Description
Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
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Product Notes
The HIV1 protease (Catalog #AAA536030) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HIV1 protease antibody reacts with Binds to recombinant Protease (HIV -1). Not tested for sterility or endotoxin content. and may cross-react with other species as described in the data sheet. AAA Biotech's HIV1 protease can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). If protein concentration is 1mg/ml, suggested starting dilutions are: ELISA and Western Blot 1:500-1:1,000 Optimal dilutions must be determined by end user. Researchers should empirically determine the suitability of the HIV1 protease for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HIV1 protease, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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