Rabbit IFN gamma Polyclonal Antibody | anti-IFN gamma antibody

IFN gamma antibody

Cat. Num. AAA534056

• Gene Names: IFNG; IFG; IFI
• Reactivity: Murine IFN gamma
• Applications: ELISA, Western Blot
• Synonyms: IFN gamma; Polyclonal Antibody; IFN gamma antibody; Polyclonal IFN gamma; Anti-IFN gamma; IFN-g; type II interferon; Interferon gamma; Immune Interferon; IFN g; MAF; T cell interferon; anti-IFN gamma antibody

• Host: Rabbit
• Reactivity: Murine IFN gamma
• Clonality: Polyclonal
• Specificity: Murine IFN gamma
• Form/Format: Lyophilized from PBS, pH 7.2. Reconstitute in sterile PBS, containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
• Sequence Length: 166

• Applicable Applications for anti-IFN gamma antibody: ELISA (EIA), Inhibition, Western Blot (WB)
• Application Notes: ELISA: 0.5-2 ug/ml; Inhibition: 0.05-0.1 ug/ml; WB: 0.1-0.2 ug/ml
• Biological Significance: IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells, which respond to IFN-gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-gamma signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-gamma stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-gamma is species-specific and is biologically active only in human and primate cells.
• Immunogen: IFN Gamma antibody was raised in rabbit using highly pure recombinant murine IFN-gamma as the immunogen.
• Preparation and Storage: Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-IFN gamma antibody

Affinity purified Rabbit polyclonal IFN gamma antibody

Product Categories/Family for anti-IFN gamma antibody

Immunology; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 184639
• NCBI GeneID: 3458
• UniProt Accession #: P01579; Q53ZV4; B5BU88
• Molecular Weight: 15.6 kDa (predicted detection band MW)
• NCBI Official Full Name: interferon-gamma
• NCBI Official Synonym Full Names: interferon, gamma
• NCBI Official Symbol: IFNG
• NCBI Official Synonym Symbols: IFG; IFI
• NCBI Protein Information: interferon gamma
• UniProt Protein Name: Interferon gamma
• UniProt Gene Name: IFNG
• UniProt Synonym Gene Names: IFN-gamma
• UniProt Entry Name: IFNG_HUMAN

NCBI Description

This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009]

Uniprot Description

IFNG: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family.

Protein type: Secreted; Membrane protein, integral; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: interferon-gamma receptor binding; cytokine activity

Biological Process: positive regulation of isotype switching to IgG isotypes; positive regulation of nitric oxide biosynthetic process; positive regulation of interleukin-23 production; positive regulation of interleukin-12 production; negative regulation of smooth muscle cell proliferation; positive regulation of osteoclast differentiation; apoptosis; positive regulation of interleukin-6 biosynthetic process; negative regulation of epithelial cell differentiation; sensory perception of mechanical stimulus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-1 beta secretion; positive regulation of killing of cells of another organism; positive regulation of membrane protein ectodomain proteolysis; cell surface receptor linked signal transduction; positive regulation of MHC class II biosynthetic process; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of T cell proliferation; cell cycle arrest; defense response to virus; regulation of the force of heart contraction; positive regulation of peptidyl-serine phosphorylation of STAT protein; response to drug; positive regulation of synaptic transmission, cholinergic; neutrophil chemotaxis; adaptive immune response; negative regulation of myelination; CD8-positive, alpha-beta T cell differentiation during immune response; unfolded protein response; cytokine and chemokine mediated signaling pathway; response to virus; positive regulation of tumor necrosis factor production; defense response to protozoan; humoral immune response; antigen processing and presentation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of interleukin-12 biosynthetic process; positive regulation of chemokine biosynthetic process; negative regulation of interleukin-17 production; protein import into nucleus, translocation; defense response to bacterium; neutrophil apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; cell motility; regulation of insulin secretion

Disease: Hepatitis C Virus, Susceptibility To; Aplastic Anemia; Mycobacterium Tuberculosis, Susceptibility To; Tuberous Sclerosis 2; Human Immunodeficiency Virus Type 1, Susceptibility To