Rat anti-Murine CD4 CD4 Monoclonal Antibody | anti-CD4 antibody

CD4 antibody (PE-CY7)

Cat. Num. AAA531993

• Gene Names: Cd4; L3T4; Ly-4
• Reactivity: Murine CD4
• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry
• Synonyms: CD4; Monoclonal Antibody; CD4 antibody (PE-CY7); Monoclonal CD4; Anti-CD4; T Cell Surface Glycoprotein CD4; T Cell Antigen T4; Ly-4; CD4_HUMAN; CD4 antigen (p55); W3/25; T cell differentiation antigen L3T4; L3T4; included; Leu3; CD4+ Lymphocyte deficiency; Lymphocyte antigen CD4; CD-4; MGC165891; W3/25 antigen; T-cell surface antigen T4/Leu-3; T cell surface antigen T4/Leu3; CD 4; CD4mut; T cell OKT4 deficiency; T cell surface antigen T4/Leu 3; p55; T cell antigen T4/LEU3; T-cell surface glycoprotein CD4; anti-CD4 antibody

• Host: Rat
• Reactivity: Murine CD4
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: GK1.5
• Specificity: Murine CD4
• Form/Format: Supplied as a liquid in PBS, with NaN3 added as preservative.
• Concentration: 0.1 mg/ml (varies by lot)
• Sequence Length: 457

• Applicable Applications for anti-CD4 antibody: Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)
• Biological Significance: CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene.
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
• Tag/Conjugate: PE-CY7
• Immunogen: CD4 antibody (PE-CY7) was raised in rat using cloned murine CTL line V4 as the immunogen.
• Preparation and Storage: Store at 4 degree C.

Related Product Information for anti-CD4 antibody

Rat monoclonal CD4 antibody (PE-CY7)

Product Categories/Family for anti-CD4 antibody

Immunology; Conjugated Monoclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 24659577
• NCBI GeneID: 12504
• UniProt Accession #: P06332
• Molecular Weight: 24,473 Da
• NCBI Official Full Name: CD4 antigen
• NCBI Official Synonym Full Names: CD4 antigen
• NCBI Official Symbol: Cd4
• NCBI Official Synonym Symbols: L3T4; Ly-4
• NCBI Protein Information: T-cell surface glycoprotein CD4
• UniProt Protein Name: T-cell surface glycoprotein CD4
• Protein Family: CD40 ligand
• UniProt Gene Name: Cd4
• UniProt Entry Name: CD4_MOUSE

Uniprot Description

CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: endoplasmic reticulum membrane; cell surface; membrane; endoplasmic reticulum lumen; integral to membrane; plasma membrane; lipid raft; external side of plasma membrane

Molecular Function: protein binding; enzyme binding; protein homodimerization activity; zinc ion binding; coreceptor activity; glycoprotein binding; protein kinase binding

Biological Process: maintenance of cellular protein localization; T cell activation; immune system process; cytokine production; T cell selection; positive regulation of calcium-mediated signaling; defense response to Gram-negative bacterium; induction by virus of cell-cell fusion in host; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; positive regulation of protein kinase activity; protein palmitoleylation; immune response; positive regulation of T cell activation; cell adhesion; regulation of T cell activation; T cell differentiation