Mouse Complement C1q Monoclonal Antibody | anti-C1QB antibody

Complement C1q antibody

Cat. Num. AAA531348

• Applications: ELISA, Immunoblot, Western Blot
• Purity: Protein A affinity chromatography
• Synonyms: Complement C1q; Monoclonal Antibody; Complement C1q antibody; Monoclonal Complement C1q; Anti-Complement C1q; C1q; Complement Cq 1; Complement Cq -1; anti-C1QB antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 242G3
• Specificity: Human complement C1q
• Purity/Purification: Protein A affinity chromatography
• Form/Format: Lyophilized powder. Reconstitute in 1 mL in distilled water. ; ; Final solution contains 0.09% sodium azide, 0.5% BSA in PBS buffer, pH 7.4. Dilute further 1:100 for Western Blotting.
• Sequence Length: 253

• Applicable Applications for anti-C1QB antibody: Suitable for inhibition experiments, Immunoblotting (Western) and ELISA.
• Application Notes: WB: 1:100
• Biological Significance: The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin. The sites are on the CH2 domain of IgG and probably on the CH4 domain of IgM. The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity.
• Cross-Reactivity: Human
• Immunogen: Complement C1q antibody was raised in mouse using human complement C1q as the immunogen.
• Preparation and Storage: Ships ambient or refrigerated. Upon receipt store at -20°C.

Related Product Information for anti-C1QB antibody

Mouse monoclonal Complement C1q antibody

Product Categories/Family for anti-C1QB antibody

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 87298828
• NCBI GeneID: 713
• NCBI Accession #: NP_000482.3
• NCBI GenBank Nucleotide #: NM_000491.3
• UniProt Accession #: P02746; Q5T959; Q96H17
• NCBI Official Full Name: complement C1q subcomponent subunit B
• NCBI Official Synonym Full Names: complement component 1, q subcomponent, B chain
• NCBI Official Symbol: C1QB
• NCBI Protein Information: complement C1q subcomponent subunit B
• UniProt Protein Name: Complement C1q subcomponent subunit B
• Protein Family: Complement C1q-like protein
• UniProt Gene Name: C1QB
• UniProt Entry Name: C1QB_HUMAN

NCBI Description

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]

Uniprot Description

C1QB: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: collagen; extracellular region; complement component C1 complex

Molecular Function: protein binding; protein homodimerization activity

Biological Process: innate immune response; complement activation, classical pathway; inner ear development; complement activation

Disease: C1q Deficiency