Complement C4 Active Protein | C4a active protein
Purified native Human Complement C4 protein
Gene Names
C4a; C4; C4b; C4-1
Purity
> 95% by SDS-PAGE
Synonyms
Complement C4; Purified native Human Complement C4 protein; Complement C4 protein; C4a active protein
Host
Human
Purity/Purification
> 95% by SDS-PAGE
Form/Format
0.2 um filtered, frozen solution in PBS, pH 7.4.
Concentration
2.3 mg/ml (E0.1%280nm=0.92) (varies by lot)
Sequence Length
1737
Source Note
Human Plasma
Biohazard
Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti HCV, HBsAg and Syphilis by FDA approved methods. However, as no test method can offer complete assurance that infectious agents are absent, handle as possibly infectious.
Protein Type
Native
Biological Significance
Component C4 interacts with C1 and C2 to form C3 convertase of the classic activation pathway. Systemic lupus erythematosus (SLE) is often associated with congenital C4 deficiency. Reduced levels of components of the classic pathway (C1, C2, C4, C3) are common after such activation, e.g. in SLE, acute serum sickness and conditions associated with circulating immune complexes. The common form present in plasma and used in test assays is the C4c form offered here.
Dry Ice Shipment
Extra charge may be applied to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Upon receipt store at -20°C. Avoid repeat freeze-thaws.
Product Categories/Family for C4a active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
147,000
NCBI Official Full Name
complement C4
NCBI Official Synonym Full Names
complement component 4A (Rodgers blood group)
NCBI Official Symbol
C4a
NCBI Official Synonym Symbols
C4; C4b; C4-1
NCBI Protein Information
complement C4
UniProt Protein Name
Complement C4
Protein Family
UniProt Gene Name
C4
UniProt Synonym Gene Names
C4a
NCBI Description
complement protein, part of the classical activation pathway; localizes to the class III region of the MHC [RGD, Feb 2006]
Uniprot Description
C4A: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory processes. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20p12
Cellular Component: extracellular region; extracellular space
Biological Process: complement activation
Research Articles on C4a
Similar Products
Product Notes
The C4a c4 (Catalog #AAA5308189) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Complement C4, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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