CKBB recombinant protein

CKBB protein

• Gene Names: CKB; BCK; B-CK; CKBB; HEL-211; HEL-S-29
• Applications: Western Blot
• Purity: > 95% pure
• Synonyms: CKBB; CKBB protein; Creatine Kinase BB protein protein; B CK protein; B-CK protein; BCK protein; Brain creatine kinase protein; Ckb protein; Creatine kinase B protein; Creatine kinase B chain protein; Creatine kinase B type protein; Creatine kinase B-type protein; Creatine Kinase BB Isoenzyme protein; Creatine kinase brain protein; Creatine protein; sphokinase BB protein; KCRB protein; CKBB recombinant protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: Supplied in lyophilized form from 20mM HEPES, pH7.0
• Sequence Length: 381

• Applicable Applications for CKBB recombinant protein: Western Blot (WB)
• Protein Type: Recombinant
• Biological Significance: Creatine Kinase BB (CK-BB) is predominately found in brain tissue and is not normally present in measurable amounts in the serum of normal adults. Serum levels, however, may increase after severe damage to tissues containing CK-BB. Elevated serum levels of CK-BB are associated with cancer of the breast, ovary, prostate, colon, and other gastrointestinal carcinomas, and for small-cell anaplastic carcinoma of the lung.
• Expression System: E Coli
• Preparation and Storage: Store at -80 degree C. Avoid frequent freeze/thaw cycles

Western Blot (WB)

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Related Product Information for CKBB recombinant protein

Purified recombinant CKBB protein

Product Categories/Family for CKBB recombinant protein

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 21536286
• NCBI GeneID: 1152
• NCBI Accession #: NP_001814.2
• NCBI GenBank Nucleotide #: NM_001823.4
• Molecular Weight: 42.3 kDa
• NCBI Official Full Name: creatine kinase B-type
• NCBI Official Synonym Full Names: creatine kinase, brain
• NCBI Official Symbol: CKB
• NCBI Official Synonym Symbols: BCK; B-CK; CKBB; HEL-211; HEL-S-29
• NCBI Protein Information: creatine kinase B-type
• UniProt Protein Name: Creatine kinase B-type
• UniProt Gene Name: CKB
• UniProt Synonym Gene Names: CKBB
• UniProt Entry Name: KCRB_HUMAN

NCBI Description

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

CKB: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family.

Protein type: EC 2.7.3.2; Amino Acid Metabolism - arginine and proline; Kinase, other

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: mitochondrion; cytosol

Molecular Function: protein binding; creatine kinase activity; ATP binding

Biological Process: substantia nigra development; creatine metabolic process; cellular chloride ion homeostasis; phosphorylation