HLAC recombinant protein

HLAC protein (His tag)

Cat. Num. AAA5304014

• Gene Names: HLA-C; HLC-C; D6S204; PSORS1; HLA-JY3
• Applications: SDS-Page
• Purity: > 90% pure
• Synonyms: HLAC; HLAC protein (His tag); HLA class I histocompatibility antigen protein; Cw-1 alpha chain protein; D6S204 protein; HLA-JY3 protein; HLC-C protein; PSORS1 protein; HLAC recombinant protein

• Host: Human
• Purity/Purification: > 90% pure
• Form/Format: Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
• Concentration: 500 ug/ml (varies by lot)
• Sequence: 25-308 aa: MGSSHHHHHH SSGLVPRGSH MGSCSHSMRY FDTAVSRPGR GEPRFISVGY VDDTQFVRFD SDAASPRGEP RAPWVEQEGP EYWDRETQKY KRQAQADRVS LRNLRGYYNQ SEDGSHTLQR MSGCDLGPDG RLLRGYDQSA YDGKDYIALN EDLRSWTAAD TAAQITQRKL EAARAAEQLR AYLEGTCVEW LRRYLENGKE TLQRAEPPKT HVTHHPLSDH EATLRCWALG FYPAEITLTW QRDGEDQTQD TELVETRPAG DGTFQKWAAV VVPSGQEQRY TCHMQHEGLQ EPLTLSWEPS SQPTIPI
• Sequence Length: 366

• Applicable Applications for HLAC recombinant protein: SDS-PAGE
• Protein Type: Recombinant
• Biological Significance: HLAC belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells.
• Expression System: E Coli
• Tag/Conjugate: His tag
• Preparation and Storage: Store at 4 degree C for up to 2 weeks. For long term storage, aliquot and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles

Related Product Information for HLAC recombinant protein

Purified recombinant MLEC protein (His tag)

Product Categories/Family for HLAC recombinant protein

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 297097
• NCBI GeneID: 3107
• UniProt Accession #: P30508; O02863; O19652; O62882; O78062; O78166; O78211; O78214; P30509; Q29768; Q31627; Q860R1; P04222; P10321; P30499; P30501; P30504; P30505; P30510; Q29960; Q29963
• Molecular Weight: 34.9 kDa
• NCBI Official Full Name: HLA-C alpha chain
• NCBI Official Synonym Full Names: major histocompatibility complex, class I, C
• NCBI Official Symbol: HLA-C
• NCBI Official Synonym Symbols: HLC-C; D6S204; PSORS1; HLA-JY3
• NCBI Protein Information: HLA class I histocompatibility antigen, Cw-1 alpha chain
• UniProt Protein Name: HLA class I histocompatibility antigen, Cw-12 alpha chain
• UniProt Gene Name: HLA-C
• UniProt Synonym Gene Names: HLAC
• UniProt Entry Name: 1C12_HUMAN

NCBI Description

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]

Uniprot Description

HLAC iso7: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; Golgi apparatus; phagocytic vesicle membrane; cell surface; endoplasmic reticulum; integral to plasma membrane; early endosome membrane; plasma membrane; extracellular region; MHC class I protein complex

Molecular Function: peptide antigen binding; TAP binding; receptor binding

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response