Goat Cathepsin H Polyclonal Antibody | anti-CTSH antibody

Cathepsin H antibody

• Gene Names: CTSH; ACC4; ACC5; CPSB; ACC-4; ACC-5; minichain
• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Cathepsin H antibody was purified by immunoaffinity purification.
• Synonyms: Cathepsin H; Polyclonal Antibody; Cathepsin H antibody; Polyclonal Cathepsin H; Anti-Cathepsin H; Cathepsin-H; anti-CTSH antibody

• Host: Goat
• Clonality: Polyclonal
• Purity/Purification: Cathepsin H antibody was purified by immunoaffinity purification.
• Form/Format: Supplied in PBS buffer containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
• Concentration: 200 ug/ml (varies by lot)
• Sequence Length: 248

• Applicable Applications for anti-CTSH antibody: Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: IP: 10-20 ug/ml; IHC: 10-20 ug/ml; WB: 1-4 ug/ml
• Biological Significance: The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in various cellular events such as peptide biosynthesis and protein degradation. The propeptide region of cathepsin H is highly homologous to other cathepsins. This region is thought to play a role in the processing of cysteine proteases.
• Cross-Reactivity: Human, Mouse, Rat
• Immunogen: Cathepsin H antibody was raised in Goat using synthetic peptide mapping at the N-terminus of human Cathepsin H as the immunogen.
• Preparation and Storage: Store at -20 degree C. For long-term storage, aliquot and freeze at -70 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-CTSH antibody

Goat polyclonal Cathepsin H antibody

Product Categories/Family for anti-CTSH antibody

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 29708
• NCBI GeneID: 1512
• UniProt Accession #: P09668; Q96NY6; Q9BUM7; B2RBK0
• Molecular Weight: 37,394 Da
• NCBI Official Full Name: cathepsin H, partial
• NCBI Official Synonym Full Names: cathepsin H
• NCBI Official Symbol: CTSH
• NCBI Official Synonym Symbols: ACC4; ACC5; CPSB; ACC-4; ACC-5; minichain
• NCBI Protein Information: pro-cathepsin H
• UniProt Protein Name: Pro-cathepsin H
• Protein Family: Pro-cathepsin
• UniProt Gene Name: CTSH
• UniProt Synonym Gene Names: CPSB
• UniProt Entry Name: CATH_HUMAN

NCBI Description

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]

Uniprot Description

CTSH: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.16; Protease

Chromosomal Location of Human Ortholog: 15q25.1

Cellular Component: extracellular space; lysosome; acrosome; outer dense fiber; cytosol

Molecular Function: peptidase activity; protein binding; HLA-A specific activating MHC class I receptor activity; protein self-association; serine-type endopeptidase activity; cysteine-type endopeptidase activity; endopeptidase activity; protein complex binding; caspase activator activity; aminopeptidase activity; kininogen binding; cysteine-type peptidase activity

Biological Process: caspase activation; adaptive immune response; response to retinoic acid; protein destabilization; membrane protein proteolysis; proteolysis; antigen processing and presentation; positive regulation of angiogenesis; positive regulation of cell proliferation; spermatogenesis; zymogen activation; surfactant homeostasis; metanephros development; immune response-regulating signal transduction; T cell mediated cytotoxicity; positive regulation of cell migration; negative regulation of apoptosis