Cat Neutrophil Activating Protein 3 ELISA Kit | NAP3 elisa kit
Cat Neutrophil Activating Protein 3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction
By similarity. Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role in the accumulation of neutrophils and monocytes at the site of infection. Induces superoxide anion generation, adhesion and chemotaxis of neutrophils, through a pertussis toxin-sensitive pathway involving MAP kinases. Ref.2 Ref.11 Ref.14 Ref.15 Ref.16 Ref.17
Catalytic activity: 2 Fe2+ + H2O2 + 2 H+ = 2 Fe3+ + 2 H2O.
Subunit structure: Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe3+ can be deposited. Ref.13 Ref.18
Subcellular location: Cytoplasm.
Domain: 12 di-nuclear ferroxidase centers are located at the interfaces between subunits related by 2-fold symmetry axes
By similarity.
Miscellaneous: According to Ref.16, colocalizes with DNA but according to Ref.12 it does not interact with DNA.
Sequence similarities: Belongs to the Dps family.
Research Articles on NAP3
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Product Notes
The Cat NAP3 dps (Catalog #AAA050939) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA050939 ELISA Kit recognizes Cat NAP3. It is sometimes possible for the material contained within the vial of "Neutrophil Activating Protein 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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