Rabbit Prostaglandin E Synthase Polyclonal Antibody | anti-PTGES antibody

Prostaglandin E Synthase Rabbit pAb

Cat. Num. AAA4756897

• Gene Names: PTGES; PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: Prostaglandin E Synthase; Polyclonal Antibody; Prostaglandin E Synthase Rabbit pAb; Prostaglandin E synthase; prostaglandin E synthase; PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1; anti-PTGES antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: Supplied in 50nM Tris-Glycine(pH7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

• Applicable Applications for anti-PTGES antibody: Western Blot (WB)
• Application Notes: WB: 1:1000
• Immunogen: A synthetic peptide of human Prostaglandin E Synthase
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot detection of Prostaglandin E Synthase in MCF7,C6,3T3,Hela cell lysates using Prostaglandin E Synthase Rabbit pAb(1:1000 diluted).Predicted band size:17KDa.Observed band size:17KDa.)

Related Product Information for anti-PTGES antibody

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

Product Categories/Family for anti-PTGES antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 4758910
• NCBI GeneID: 9536
• NCBI Accession #: NP_004869.1
• NCBI GenBank Nucleotide #: NM_004878.4
• UniProt Accession #: O14684; O14900; Q5SZC0
• Molecular Weight: 17,102 Da
• NCBI Official Full Name: prostaglandin E synthase
• NCBI Official Synonym Full Names: prostaglandin E synthase
• NCBI Official Symbol: PTGES
• NCBI Official Synonym Symbols: PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
• NCBI Protein Information: prostaglandin E synthase; MGST1-like 1; p53-induced gene 12 protein; p53-induced apoptosis protein 12; glutathione S-transferase 1-like 1; microsomal prostaglandin E synthase 1; microsomal prostaglandin E synthase-1; tumor protein p53 inducible protein 12
• UniProt Protein Name: Prostaglandin E synthase
• Protein Family: Prostaglandin E synthase
• UniProt Gene Name: PTGES
• UniProt Synonym Gene Names: MGST1L1; MPGES1; PGES; PIG12; MGST1-L1; MPGES-1
• UniProt Entry Name: PTGES_HUMAN

NCBI Description

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

Uniprot Description

PTGES: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family.

Protein type: EC 5.3.99.3; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Nuclear envelope; Membrane protein, multi-pass; Isomerase

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; nuclear envelope lumen; integral to membrane

Molecular Function: glutathione binding; prostaglandin-E synthase activity

Biological Process: negative regulation of cell proliferation; chronic inflammatory response; response to retinoic acid; response to cytokine stimulus; cyclooxygenase pathway; arachidonic acid metabolic process; response to lipopolysaccharide; response to calcium ion; signal transduction; prostaglandin biosynthetic process; response to organic cyclic substance; acute inflammatory response; prostaglandin metabolic process