Rabbit PIP5KI gamma Polyclonal Antibody | anti-PIP5KIgamma antibody

PIP5KI gamma Rabbit pAb

Cat. Num. AAA4756851

• Gene Names: Pip5k1c; AI115456; AI835305; Pip5kIgamma
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunoprecipitation
• Purity: Affinity purified
• Synonyms: PIP5KI gamma; Polyclonal Antibody; PIP5KI gamma Rabbit pAb; Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; phosphatidylinositol-4-phosphate 5-kinase; type 1 gamma; AI115456; AI835305; Pip5kIgamma; anti-PIP5KIgamma antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: High expression in brain. Also detected in lung, thymus, heart, testicle, kidney and embryo. Highly expressed in forebrain, in particular in cerebellum, hippocampus and cerebral cortex.
• Purity/Purification: Affinity purified
• Form/Format: Supplied in 50nM Tris-Glycine(pH7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

• Applicable Applications for anti-PIP5KIgamma antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: WB: 1:1000-1:5000; IP: 1:20-1:50
• Immunogen: Recombinant protein of mouse PIP5KI gamma
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot detection of PIP5KI gamma in MCF7 cell lysates using PIP5KI gamma Rabbit pAb(1:1000 diluted).Predicted band size:73KDa.Observed band size:90,87 KDa.)

Related Product Information for anti-PIP5KIgamma antibody

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2). PtdIns(4, 5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3), another second messenger. The majority of PtdIns(4, 5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion, cell polarization and cell migration. Together with PIP5K1A is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle attachment by generating the pool of PtdIns(4, 5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport. Controls the plasma membrane pool of PtdIns(4, 5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2). Required for clathrin-coated pits assembly at the synapse. Participates in cell junction assembly. Modulates adherens junctions formation by facilitating CDH1 trafficking. Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions. Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins. Required for uropodium formation and retraction of the cell rear during directed migration. Has a role in growth factor- stimulated directional cell migration and adhesion. Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor. Negative regulator of T-cell activation and adhesion. Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor. Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth.

Product Categories/Family for anti-PIP5KIgamma antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 78099089
• NCBI GeneID: 18717
• UniProt Accession #: O70161; Q505A1; Q80TW9; Q8VCU5
• Molecular Weight: 72,408 Da
• NCBI Official Full Name: Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
• NCBI Official Synonym Full Names: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
• NCBI Official Symbol: Pip5k1c
• NCBI Official Synonym Symbols: AI115456; AI835305; Pip5kIgamma
• NCBI Protein Information: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; PIP5K1-gamma; ptdIns(4)P-5-kinase 1 gamma; phosphatidylinositol 4-phosphate 5-kinase type I gamma; phosphatidylinositol-4-phosphate 5-kinase type I gamma; phosphatidylinositol-4-phosphate 5-kinase ty
• UniProt Protein Name: Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
• UniProt Gene Name: Pip5k1c
• UniProt Synonym Gene Names: Kiaa0589; PIP5K1-gamma; PtdIns(4)P-5-kinase 1 gamma; PIP5KIgamma
• UniProt Entry Name: PI51C_MOUSE

Uniprot Description

PIP5K1C: a member of the type I phosphatidylinositol-4-phosphate 5-kinase family of enzymes. A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.

Protein type: Kinase, lipid; Motility/polarity/chemotaxis; EC 2.7.1.68; Carbohydrate Metabolism - inositol phosphate

Cellular Component: cell projection; membrane; cell; cytoplasm; plasma membrane; cell junction

Molecular Function: transferase activity; protein binding; phosphatidylinositol phosphate kinase activity; 1-phosphatidylinositol-4-phosphate 5-kinase activity; nucleotide binding; kinase activity; ATP binding

Biological Process: exocytosis; axonogenesis; cytoskeletal anchoring; phosphoinositide phosphorylation; endocytosis; phosphatidylinositol metabolic process; cell adhesion; chemotaxis; phosphorylation; phagocytosis