Rabbit anti-Human, Mouse HOXA9 Polyclonal Antibody | anti-HOXA9 antibody

HOXA9 Rabbit pAb

Cat. Num. AAA4754961

• Gene Names: HOXA9; HOX1; ABD-B; HOX1G; HOX1.7
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: HOXA9; Polyclonal Antibody; HOXA9 Rabbit pAb; homeobox A9; HOX1; ABD-B; HOX1G; HOX1.7; anti-HOXA9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-HOXA9 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:200-1:1000; ELISA: 1:5000-1:10,000; IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human HOXA9
• Conjugation: Unconjugated
• Molecular Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.
• Modification: Unmodified
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Mouse kidney tissue, Mouse spleen tissue, Primary antibody: 162920(HOXA9 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds)

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human brain tissue using 162920(HOXA9 Antibody) at dilution 1/30.(Original magnification: ×200))

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using 162920(HOXA9 Antibody) at dilution 1/30. (Original magnification: ×200))

Related Product Information for anti-HOXA9 antibody

This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.

Product Categories/Family for anti-HOXA9 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 6166219
• NCBI GeneID: 3205
• UniProt Accession #: P31269; O43369; O43429; Q99820
• Molecular Weight: 272
• NCBI Official Full Name: Homeobox protein Hox-A9
• NCBI Official Synonym Full Names: homeobox A9
• NCBI Official Symbol: HOXA9
• NCBI Official Synonym Symbols: HOX1; ABD-B; HOX1G; HOX1.7
• NCBI Protein Information: homeobox protein Hox-A9; homeobox protein Hox-1G; homeodomain protein HOXA9
• UniProt Protein Name: Homeobox protein Hox-A9
• Protein Family: Homeobox protein
• UniProt Gene Name: HOXA9
• UniProt Synonym Gene Names: HOX1G
• UniProt Entry Name: HXA9_HUMAN

NCBI Description

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]

Uniprot Description

HOXA9: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98. A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2. Belongs to the Abd-B homeobox family.

Protein type: DNA-binding; Oncoprotein

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus

Molecular Function: protein binding; enzyme binding; sequence-specific DNA binding

Biological Process: embryonic forelimb morphogenesis; negative regulation of myeloid cell differentiation; transcription, DNA-dependent; multicellular organismal development; embryonic skeletal development; male gonad development; uterus development; endothelial cell activation; anterior/posterior pattern formation; regulation of transcription, DNA-dependent; mammary gland development; single fertilization; spermatogenesis; proximal/distal pattern formation