Mouse anti-Human Cystatin C Monoclonal Antibody | anti-CYC antibody

Anti-Cystatin C Mouse mAb

Cat. Num. AAA475177

• Gene Names: CST3; ARMD11; HEL-S-2
• Reactivity: Human
• Applications: ELISA
• Synonyms: Cystatin C; Monoclonal Antibody; Anti-Cystatin C Mouse mAb; CST3; Cystatin 3; anti-CYC antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 6F12-C7-D8
• Concentration: 3.0mg/ml (varies by lot)
• Sequence Length: 146

• Applicable Applications for anti-CYC antibody: sELISA Capture
• Immunogen: Recombinant human cystatin c protein.

Testing Data

(Standard Curve for Human Cystatin C: Capture Antibody Mouse mAb [6F12-C7-D8] to Human Cystatin C at 4mug/ml and Detector Antibody Mouse mAb [7F6-A5-F3]to Human Cystatin C at 0.5mug/ml.)

Related Product Information for anti-CYC antibody

Entrez Summary: Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin or neuroendocrine basic polypeptide), [2] a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function.Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease.It also seems to play a role in brain disorders involving amyloid (a specific type of protein deposition), such as Alzheimer's disease.In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids.It is found in virtually all tissues and body fluids.It is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes).Cystatin C belongs to the type 2 cystatin gene family.

NCBI and Uniprot Product Information

• NCBI GI #: 4503107
• NCBI GeneID: 1471
• NCBI Accession #: NP_000090.1
• NCBI GenBank Nucleotide #: NM_000099.3
• UniProt Accession #: P01034; Q6FGW9; B2R5J9; D3DW42
• Molecular Weight: 13
• NCBI Official Full Name: cystatin-C
• NCBI Official Synonym Full Names: cystatin C
• NCBI Official Symbol: CST3
• NCBI Official Synonym Symbols: ARMD11; HEL-S-2
• NCBI Protein Information: cystatin-C
• UniProt Protein Name: Cystatin-C
• Protein Family: Cytochrome
• UniProt Gene Name: CST3

NCBI Description

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]

Uniprot Description

CST3: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Defects in CST3 are the cause of amyloidosis type 6 (AMYL6); also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low. Genetic variations in CST3 are associated with age- related macular degeneration type 11 (ARMD11). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the cystatin family.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: extracellular region; extracellular space

Molecular Function: beta-amyloid binding; cysteine protease inhibitor activity; endopeptidase inhibitor activity; identical protein binding; protease binding; protein binding

Biological Process: cellular protein metabolic process; defense response; fibril organization and biogenesis; negative regulation of peptidase activity; negative regulation of proteolysis; regulation of tissue remodeling

Disease: Cerebral Amyloid Angiopathy, Cst3-related; Macular Degeneration, Age-related, 11