Rabbit anti-Human IRS2 Polyclonal Antibody | anti-IRS2 antibody

Rabbit anti IRS2 (pS1001) Polyclonal Antibody

Cat. Num. AAA460346

• Gene Names: IRS2; IRS-2
• Reactivity: Human
• Applications: ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Purified by site-modified Epitope Affinity Purification.
• Synonyms: IRS2; Polyclonal Antibody; Rabbit anti IRS2 (pS1001) Polyclonal Antibody; Insulin receptor substrate 2; anti-IRS2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by site-modified Epitope Affinity Purification.
• Form/Format: Supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
• Sequence Length: 319

• Applicable Applications for anti-IRS2 antibody: ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: ELISA: 0.01-0.1 ug/ml; Flow Cytometry: 5-10 ug/ml; Immunohistochemistry: 2-10 ug/ml; Immunoprecipitation: 2-5 ug/ml; Western Blot: 0.1-1 ug/ml
• Preparation and Storage: The antibodies are stable for 12 months from date of receipt when stored at -20 degree C. The antibodies can be stored at 2 degree C - 8 degree C for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 958725656
• NCBI GeneID: 8660
• Molecular Weight: 137,334 Da
• NCBI Official Full Name: IRS2, partial
• NCBI Official Synonym Full Names: insulin receptor substrate 2
• NCBI Official Symbol: IRS2
• NCBI Official Synonym Symbols: IRS-2
• NCBI Protein Information: insulin receptor substrate 2
• UniProt Protein Name: Insulin receptor substrate 2
• Protein Family: Insulin receptor substrate
• UniProt Gene Name: IRS2
• UniProt Synonym Gene Names: IRS-2

NCBI Description

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

Uniprot Description

IRS2: May mediate the control of various cellular processes by insulin. Interacts with PHIP.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cytosol; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; insulin receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; protein binding; Ras guanyl-nucleotide exchange factor activity; signal transducer activity

Biological Process: axon guidance; cellular response to insulin stimulus; glucose metabolic process; insulin receptor signaling pathway; lipid homeostasis; MAPKKK cascade; negative regulation of B cell apoptosis; negative regulation of kinase activity; phosphoinositide-mediated signaling; positive regulation of B cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of insulin secretion; regulation of lipid metabolic process; regulation of phosphoinositide 3-kinase cascade; response to glucose stimulus; signal transduction

Disease: Diabetes Mellitus, Noninsulin-dependent