Mouse Toll Like Receptor 1 (TLR1) ELISA Kit | TLR1 elisa kit

Mouse Toll Like Receptor 1 (TLR1) ELISA Kit

Cat. Num. AAA456250

• Reactivity: Mouse
• Synonyms: Toll Like Receptor 1 (TLR1); Mouse Toll Like Receptor 1 (TLR1) ELISA Kit; TLR1 elisa kit

• Reactivity: Mouse
• Sequence Length: 795

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.312-20ng/mL
• Sensitivity: 0.108ng/mL
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 449784903
• NCBI GeneID: 21897
• NCBI Accession #: NP_001263374.1
• NCBI GenBank Nucleotide #: NM_001276445.1
• UniProt Accession #: Q9EPQ1; Q9EPW5
• Molecular Weight: 90,673 Da
• NCBI Official Full Name: toll-like receptor 1
• NCBI Official Synonym Full Names: toll-like receptor 1
• NCBI Official Symbol: Tlr1
• NCBI Protein Information: toll-like receptor 1
• UniProt Protein Name: Toll-like receptor 1
• Protein Family: Toll-like receptor
• UniProt Gene Name: Tlr1
• UniProt Synonym Gene Names: TIL

Uniprot Description

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (). Acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712).