Human Filamin A Alpha (FLNa) ELISA Kit | FLNa elisa kit

Human Filamin A Alpha (FLNa) ELISA Kit

Cat. Num. AAA455122

• Gene Names: FLNA; FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280
• Reactivity: Human
• Synonyms: Filamin A Alpha (FLNa); Human Filamin A Alpha (FLNa) ELISA Kit; ABP280 FLN-A ABPX FLN FLN1 FMD MNS NHBP OPD OPD1 OPD2 Actin Binding Protein 280 Endothelial actin-binding protein Filamin-1 Non-muscle filamin; FLNa elisa kit

• Reactivity: Human
• Sequence Length: 2647

• Samples: Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 1.875-120ng/mL
• Sensitivity: 0.72ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 160420317
• NCBI GeneID: 2316
• NCBI Accession #: NP_001104026.1
• NCBI GenBank Nucleotide #: NM_001110556.1
• UniProt Accession #: P21333; Q5HY53; Q5HY55; Q8NF52; E9KL45
• Molecular Weight: 280,018 Da
• NCBI Official Full Name: filamin-A isoform 2
• NCBI Official Synonym Full Names: filamin A
• NCBI Official Symbol: FLNA
• NCBI Official Synonym Symbols: FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280
• NCBI Protein Information: filamin-A
• UniProt Protein Name: Filamin-A
• Protein Family: Filamin
• UniProt Gene Name: FLNA
• UniProt Synonym Gene Names: FLN; FLN1; FLN-A; ABP-280

NCBI Description

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Uniprot Description

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintainance ().