Human Lysophosphatidic Acid Receptor 1 (LPAR1) ELISA Kit | LPAR1 elisa kit

Human Lysophosphatidic Acid Receptor 1 (LPAR1) ELISA Kit

Cat. Num. AAA452926

• Gene Names: LPAR1; EDG2; LPA1; VZG1; GPR26; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3
• Reactivity: Human
• Synonyms: Lysophosphatidic Acid Receptor 1 (LPAR1); Human Lysophosphatidic Acid Receptor 1 (LPAR1) ELISA Kit; API3; Baculoviral IAP repeat-containing protein 4; BIRC4; E3 ubiquitin-protein ligase XIAP; hIAP3; hIAP-3; hILP; IAP3; IAP-3; IAP-like protein; ILP; Inhibitor of apoptosis protein 3; X-linked IAP; X-; LPAR1 elisa kit

• Reactivity: Human
• Sequence Length: 365

• Samples: Tissue homogenates, cell lysates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.312-20ng/mL
• Sensitivity: 0.112ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 16950636
• NCBI GeneID: 1902
• NCBI Accession #: NP_001392.2
• NCBI GenBank Nucleotide #: NM_001401.3
• UniProt Accession #: Q92633; O00656; O00722; P78351; B4DK36
• Molecular Weight: 41,346 Da
• NCBI Official Full Name: lysophosphatidic acid receptor 1
• NCBI Official Synonym Full Names: lysophosphatidic acid receptor 1
• NCBI Official Symbol: LPAR1
• NCBI Official Synonym Symbols: EDG2; LPA1; VZG1; GPR26; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3
• NCBI Protein Information: lysophosphatidic acid receptor 1
• UniProt Protein Name: Lysophosphatidic acid receptor 1
• Protein Family: Lysophosphatidic acid receptor
• UniProt Gene Name: LPAR1
• UniProt Synonym Gene Names: EDG2; LPA1; LPA receptor 1; LPA-1

NCBI Description

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca2+ levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain ().