Mouse Survivin (Surv) ELISA Kit | Surv elisa kit

Mouse Survivin (Surv) ELISA Kit

Cat. Num. AAA452636

• Gene Names: Birc5; Api4; TIAP; AAC-11; survivin40
• Reactivity: Mouse
• Synonyms: Survivin (Surv); Mouse Survivin (Surv) ELISA Kit; BIRC5; API4; EPR-1; Baculoviral Inhibitor Of Apoptosis Repeat Containing 5; Apoptosis Inhibitor 4; Survivin Variant 3 Alpha; Surv elisa kit

• Reactivity: Mouse
• Sequence Length: 121

• Samples: Tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 15.625-1000pg/mL
• Sensitivity: 5.6pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 59859890
• NCBI GeneID: 11799
• NCBI Accession #: NP_001012273.1
• NCBI GenBank Nucleotide #: NM_001012273.1
• UniProt Accession #: O70201; Q923F7; Q9WU53; Q9WU54
• Molecular Weight: 4,670 Da
• NCBI Official Full Name: baculoviral IAP repeat-containing protein 5 isoform 3
• NCBI Official Synonym Full Names: baculoviral IAP repeat-containing 5
• NCBI Official Symbol: Birc5
• NCBI Official Synonym Symbols: Api4; TIAP; AAC-11; survivin40
• NCBI Protein Information: baculoviral IAP repeat-containing protein 5
• UniProt Protein Name: Baculoviral IAP repeat-containing protein 5
• UniProt Gene Name: Birc5
• UniProt Synonym Gene Names: Api4; Iap4

NCBI Description

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]

Uniprot Description

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 ().