Human Galectin 9 (GAL9) ELISA Kit | GAL9 elisa kit

Human Galectin 9 (GAL9) ELISA Kit

Cat. Num. AAA450240

• Gene Names: LGALS9; HUAT; LGALS9A
• Reactivity: Human
• Synonyms: Galectin 9 (GAL9); Human Galectin 9 (GAL9) ELISA Kit; LGALS9; Ecalectin; Lectin; Galactoside-Binding Soluble 9; Tumor antigen HOM-HD-21; GAL9 elisa kit

• Reactivity: Human
• Sequence Length: 246

• Samples: Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 78.125-5000pg/mL
• Sensitivity: 34pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 1054470958
• NCBI GeneID: 3965
• NCBI Accession #: NP_001317092.1
• NCBI GenBank Nucleotide #: NM_001330163.1
• UniProt Accession #: O00182; O14532; O75028; Q3B8N1; Q53FQ0; Q8WYQ7; Q9NQ58; A7VJG6; F8W9W4
• Molecular Weight: 38,321 Da
• NCBI Official Full Name: galectin-9 isoform 3
• NCBI Official Synonym Full Names: galectin 9
• NCBI Official Symbol: LGALS9
• NCBI Official Synonym Symbols: HUAT; LGALS9A
• NCBI Protein Information: galectin-9
• UniProt Protein Name: Galectin-9
• Protein Family: Gallinacin
• UniProt Gene Name: LGALS9
• UniProt Synonym Gene Names: Gal-9

NCBI Description

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (). Highly selective to the anion urate ().