Reactivity Chart
Goat CX43 Polyclonal Antibody | anti-CX43 antibody
Connexin 43 Polyclonal Antibody
Western blot: 1:500-1:2,000
Immunofluorescence: 1:50-1:250
Immunohistochemistry (parafin): 1:250-1:800
Immunohistochemistry (frozen): 1:250-1:800
Reactivity Chart
Reactivity Chart
Testing Data
Testing Data
Goat polyclonal to connexin 43, which is a member of the connexin family. Cx43 is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. This protein is the major protein of gap junctions in embryonic development and in the heart that are thought to have a crucial role in the synchronized contraction of the heart.
NCBI and Uniprot Product Information
Uniprot Description
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Ref.1Plays a role in regulation of fin bone size and growth. Ref.1
Subunit structure: A connexon is composed of a hexamer of connexins.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction › gap junction.
Tissue specificity: Expressed in adult ovary, heart, lens and liver. In growing caudal fins, expressed in cells flanking the germinal region of newly growing segments and in osteoblasts at segment boundaries. Ref.1 Ref.2 Ref.5
Developmental stage: Expressed both maternally and zygotically. Zygotic expression is initiated before gastrulation and persists through to day 5 of development. Levels increase in late somitogenesis, and late embryonic and early larval stages. Embryonic expression is observed in many developing tissues and organs, including the notochord and brain, and heart and vasculature. Detected throughout the lens at 24 hours post-fertilization (hpf), but by 3-4 days development, restricted to the lateral epithelium and differentiating cells in the equatorial region. Ref.2 Ref.5
Disruption phenotype: Morpholino knockdown of the protein results in heart folding defects, reduced hematopoiesis and small eyes. Ref.1
Sequence similarities: Belongs to the connexin family. Alpha-type (group II) subfamily.
Research Articles on CX43
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Product Notes
The CX43 gja1 (Catalog #AAA448055) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Connexin 43 Polyclonal Antibody reacts with Reacts against human, rat, mouse, canine and monkey proteins and may cross-react with other species as described in the data sheet. AAA Biotech's CX43 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Western Blot (WB). Usage: Western blot: 1:500-1:2,000 Immunofluorescence: 1:50-1:250 Immunohistochemistry (parafin): 1:250-1:800 Immunohistochemistry (frozen): 1:250-1:800. Researchers should empirically determine the suitability of the CX43 gja1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CX43, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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