T1/ST2 (IL-33 R) Monoclonal Antibody | anti-T1/ST2 antibody
Monocloncal Antibody to mouse T1/ST2 Biotinylated
Applications
Flow Cytometry, Functional Assay, Immunoprecipitation
Synonyms
T1/ST2 (IL-33 R); Monoclonal Antibody; Monocloncal Antibody to mouse T1/ST2 Biotinylated; T1/ST2 (IL-33 R) Monoclonal Antibody; Biotinylated; anti-T1/ST2 antibody
Clonality
Monoclonal
Isotype
IgG1 (light chain not isotyped)
Clone Number
DJ8
Specificity
This clone recognizes the membrane anchored murine T1M protein on the surface of T helper 2 cells and mast cells. T1M appears on fetal blood derived mast cell progenitors before they express the Fce RI, on IL-3-dependent bone marrow derived mast cells and on mature peritoneal mast cells. The antibody detects T1S protein consisting only of the extracellular portion of the protein, which is secreted from growth factor and proinflammatory cytokine-stimulated murine fibroblasts.
Form/Format
The antibody is supplied in PBS, with 0.1% sodium azide as preservative and purified over protein G-sepharose. The characteristics of each lot are tested by FACS analysis with bone marrow derived mast cells.
Concentration
0.5ml (1mg/ml) (varies by lot)
Applicable Applications for anti-T1/ST2 antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
Immunogen
Eukariotically expressed fusion protein of mouse T1 ectodomain and human immunoglobulin Fc domain.
Data Specifications
Rat anti-Mouse T1/ST2 biotinylated mAb
How To Use
This antibody allows the identification and purification of murine T helper 2 cells and all forms of murine mast cells.
Related Product Information for anti-T1/ST2 antibody
Mouse T1/ST2 (IL-33 R) biotinylated monoclonal antibody (clone DJ8) for the identification and purification of Th2 cells and all forms of murine mast cells.
Overview: T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed on mast cells and Th2 cells. It is a selective marker for both murine and human Th2 lymphocytes and plays a role in regulating inflammatory responses. IL-33 is a recently identified member of the IL-1 family of cytokines and is involved in Th2 mediated immune responses. IL-33 mediates its biological effects via T1/ST2 binding. The roles of IL-33 and T1/ST2 (IL-33Ra) have been investigated in many immune responses such as allergy, asthma, rheumatoid arthritis and osteoarthritis.
Overview: T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed on mast cells and Th2 cells. It is a selective marker for both murine and human Th2 lymphocytes and plays a role in regulating inflammatory responses. IL-33 is a recently identified member of the IL-1 family of cytokines and is involved in Th2 mediated immune responses. IL-33 mediates its biological effects via T1/ST2 binding. The roles of IL-33 and T1/ST2 (IL-33Ra) have been investigated in many immune responses such as allergy, asthma, rheumatoid arthritis and osteoarthritis.
Product Categories/Family for anti-T1/ST2 antibody
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Product Notes
The T1/ST2 (Catalog #AAA442001) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's T1/ST2 (IL-33 R) can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the T1/ST2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "T1/ST2 (IL-33 R), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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