Rabbit Survivin Polyclonal Antibody | anti-BIRC5 antibody

Survivin (C19) Antibody

Cat. Num. AAA440101

• Reactivity: Human, canine
• Applications: Western Blot
• Synonyms: Survivin; Polyclonal Antibody; Survivin (C19) Antibody; anti-BIRC5 antibody

• Host: Rabbit
• Reactivity: Human, canine
• Clonality: Polyclonal
• Specificity: Recognizes Human and Dog Survivin
• Form/Format: 200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
• Concentration: 0.200 mg/ml (varies by lot)
• Sequence Length: 142

• Applicable Applications for anti-BIRC5 antibody: Western Blot (WB)
• Application Notes: Western blotting starting dilution: 1:200.
• Origin: Survivin (C19) is an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the carboxy terminus of human Survivin.
• Immunogen: A synthetic peptide mapping to the carboxy terminus of human Survivin.
• Preparation and Storage: Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.

Related Product Information for anti-BIRC5 antibody

Survivin is a member of the inhibitor of apoptosis protein (IAP) family, which includes NAIP, cIAP1, cIAP2, XIAP, Ts-XIAP, ML-IAP and Apollon. (4) Survivin has been implicated in both apoptosis inhibition and cell cycle control. (3). Survivin expression has been described during embryonic development and in adult cancerous tissues, with greatly reduced expression in adult normal differentiated tissues, particularly if their proliferation index is low. (2) Survivin becomes prominently expressed in transformed cell lines and in all the most common human cancers of lung, colon, pancreas, prostate and breast, in vivo. (1)

References

1. Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 1997 Aug;3(8):917-21. 2.O'Driscoll L, Linehan R, Clynes M. Survivin: role in normal cells and in pathological conditions. Curr Cancer Drug Targets. 2003 Apr;3(2):131-52. 3. Song Z, Liu S, He H, Hoti N, Wang Y, Feng S, Wu M. A single amino acid change (Asp 53 --> Ala53) converts Survivin from anti-apoptotic to pro-apoptotic. Mol Biol Cell. 2004 Mar;15(3):1287-96. Epub 2003 Dec 29.4.Reed, John. The Survivin saga goes in vivo. J Clin Invest, October 2001, Volume 108, Number 7, 965-969.

NCBI and Uniprot Product Information

• NCBI GI #: 50978646
• NCBI GeneID: 403540
• NCBI Accession #: NP_001003019.1
• NCBI GenBank Nucleotide #: NM_001003019.1
• UniProt Accession #: Q8I009; Q5XPZ7; Q6L673
• Molecular Weight: 16,271 Da
• UniProt Protein Name: Baculoviral IAP repeat-containing protein 5
• Protein Family: Baculoviral IAP repeat-containing protein
• UniProt Gene Name: BIRC5
• UniProt Entry Name: BIRC5_CANFA

Uniprot Description

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokenesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 ().