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Western Blot (WB)

Rabbit betaCatenin Polyclonal Antibody

beta-Catenin (C18) Antibody

Reactivity
Mouse, rat, human
Applications
Western Blot, Immunoprecipitation, Immunohistochemistry
Synonyms
betaCatenin; Polyclonal Antibody; beta-Catenin (C18) Antibody; anti-betaCatenin antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse, rat, human
Clonality
Polyclonal
Specificity
Mouse, rat, and human beta-Catenin
Form/Format
200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
Concentration
0.200 mg/ml (varies by lot)
Applicable Applications for anti-betaCatenin antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes
Western blot anlaysis of beta-catenin expression in A431 whole cell lysates.
Origin
beta-catenin (C18) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the carboxy terminal domain of human beta-catenin.
Immunogen
Synthetic peptide mapping to the carboxy terminal domain of human beta-catenin.
Preparation and Storage
Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.

Western Blot (WB)

Western Blot (WB)
Related Product Information for anti-betaCatenin antibody
The multifunctional beta-catenin protein was originally identified through its association with the cadherin class of cell adhesion proteins (1&2). It was later found to be an integral part of signal transduction pathways and the best studied is the Wnt/beta-catenin pathway (3). Wnt signaling inhibits the degradation of beta-catenin and as a result beta-catenin becomes transcriptionally active (3-5). The deregulation of Wnt signaling leads to the accumulation of beta-catenin, allowing it to become transcriptionally active for a number of genes. Many of these genes are associated with cancer, such as colorectal cancer and melanomas (3&4).
References
1. Hinck L, Nathke IS, Papkoff J, Nelson WJ. 1994. ?-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways. Trends Biochem Sci. 19(12):538-542.2. Bullions LC, Levine AJ. 1998. The role of ?-catenin in cell adhesion, signal transduction, and cancer. Curr Opin Oncol. 10(1):81-87.3. Moon RT, Bowerman B, Boutros M, Perrimon N. 2002. The promise and perils of Wnt signaling through ?-catenin. Science 296(5573):1644-1646.4. Li H, Pamukcu R, Thompson WJ. 2002. ?-catenin signaling: therapeutic strategies in oncology. Cancer Biol Ther. (6):621-625.5. Hecht A, Kemler R. 2000. Curbing the nuclear activities of ?-catenin. Control over Wnt target gene expression. EMBO 1(1):24-28.

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Product Notes

The betaCatenin (Catalog #AAA440068) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The beta-Catenin (C18) Antibody reacts with Mouse, rat, human and may cross-react with other species as described in the data sheet. AAA Biotech's betaCatenin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC). Western blot anlaysis of beta-catenin expression in A431 whole cell lysates. Researchers should empirically determine the suitability of the betaCatenin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "betaCatenin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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