Mouse anti-Human Interferon alpha-1 (IFNA1) Monoclonal Antibody | anti-IFNA1 antibody

Interferon alpha-1 (IFNA1)

Cat. Num. AAA4380991

• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: Interferon alpha-1 (IFNA1); Monoclonal Antibody; IFN alpha; IFN alpha 1/13; IFN alpha 1b; Interferon alpha 13 (IFNA13); Interferon alpha leukocyte (IFL); Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); LeIF D; anti-IFNA1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Specificity: This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 189

• Applicable Applications for anti-IFNA1 antibody: Flow Cytometry (FC/FACS), Western Blot (WB), Immunohistochemistry (IHC) Frozen, Immunofluorescence (IF)
• Application Notes: FC/FACS: 0.5-1ug/million cells; WB: 1-2ug/ml; IF: 0.5-1ug/ml
• Positive Control: Stimulated human peripheral blood mononuclear cells.
• Immunogen: Purified recombinant human IFN-alpha1
• Cellular Localization: Cytoplasmic & Extracellular (Secreted)
• Hu-chromosome Location: 9q22
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-Page

(SDS-PAGE Analysis Purified Interferon alpha-1 Mouse Monoclonal Antibody (2-48). Confirmation of Purity and Integrity of Antibody.)

References

1. Capon DJ et al. Mol Cell Biol 1985, 5(4):768-779. 2. Sen GC et al. J Biol Chem 1992, 267(8):5017-5020. 3. Pestka S et al. Annu Rev Biochem 1987, 56:727-777

NCBI and Uniprot Product Information

• NCBI GI #: 124455
• UniProt Accession #: P01562
• Molecular Weight: 16-27kDa
• NCBI Official Full Name: Interferon alpha-1/13
• UniProt Protein Name: Interferon alpha-1/13
• Protein Family: Interferon
• UniProt Gene Name: IFNA1
• UniProt Synonym Gene Names: IFN-alpha-1/13; LeIF D
• UniProt Entry Name: IFNA1_HUMAN

Uniprot Description

IFNA1/13: a cytokine that belongs to the alpha/beta interferon family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p22

Cellular Component: extracellular space; extracellular region

Molecular Function: interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; regulation of MHC class I biosynthetic process; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; B cell differentiation; natural killer cell activation during immune response; innate immune response; blood coagulation; defense response to virus; positive regulation of peptidyl-serine phosphorylation of STAT protein