Melanocortin 3 Receptor Assay System | MC3R assay system
Melanocortin 3 Receptor (MC3R) ACTOne Stable Cell Line
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]
Uniprot Description
MC3R: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 20q13.2-q13.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: neuropeptide binding; protein binding; melanocortin receptor activity; peptide hormone binding; melanocyte stimulating hormone receptor activity
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; homoiothermy; regulation of heart rate; regulation of blood pressure; positive regulation of cAMP biosynthetic process; sodium ion homeostasis; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); circadian regulation of gene expression
Disease: Body Mass Index Quantitative Trait Locus 9; Mycobacterium Tuberculosis, Susceptibility To
Research Articles on MC3R
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Product Notes
The MC3R mc3r (Catalog #AAA433606) is an Assay System and is intended for research purposes only. The product is available for immediate purchase. cAMP dependent human MC3R cell-based assay; cell-based high-throughput screening of human MC3R inhibitors. Researchers should empirically determine the suitability of the MC3R mc3r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Melanocortin 3 Receptor, Assay System" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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