TRIM5 / RNF88 Blocking Peptide | TRIM5 blocking peptide

TRIM5 / RNF88 Immunizing Peptide

Cat. Num. AAA428144

• Gene Names: TRIM5; RNF88; TRIM5alpha
• Reactivity: Human
• Synonyms: TRIM5 / RNF88; TRIM5 / RNF88 Immunizing Peptide; TRIM5; RNF88; tripartite motif-containing 5; TRIM5alpha; tripartite motif protein 5; tripartite motif protein TRIM5; OTTHUMP00000069812; tripartite motif protein TRIM; tripartite motif-containing protein 5 alpha; TRIM5 blocking peptide

• Reactivity: Human
• Form/Format: 100ug of dried peptide
• Sequence: ASGILVNVKEEVTC
• Sequence Length: 493

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 14719418
• NCBI GeneID: 85363
• NCBI Accession #: NP_149023.1; NP_149083.1; NP_149084.1
• NCBI GenBank Nucleotide #: NM_033034.1
• Molecular Weight: 29,677 Da
• NCBI Official Full Name: tripartite motif protein TRIM5 isoform alpha
• NCBI Official Synonym Full Names: tripartite motif containing 5
• NCBI Official Symbol: TRIM5
• NCBI Official Synonym Symbols: RNF88; TRIM5alpha
• NCBI Protein Information: tripartite motif-containing protein 5
• UniProt Protein Name: Tripartite motif-containing protein 5
• Protein Family: Tripartite motif-containing protein
• UniProt Gene Name: TRIM5
• UniProt Synonym Gene Names: RNF88
• UniProt Entry Name: TRIM5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

Uniprot Description

TRIM5: Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity. Belongs to the TRIM/RBCC family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: identical protein binding; ligase activity; pattern recognition receptor activity; protein binding; protein binding, bridging; protein homodimerization activity; protein kinase binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: activation of innate immune response; activation of NF-kappaB transcription factor; autophagy; defense response to virus; innate immune response; negative regulation of virion penetration into host cell; pattern recognition receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPKKK cascade; positive regulation of transcription factor activity; regulation of lipopolysaccharide-mediated signaling pathway; regulation of protein localization; viral reproduction