KCNIP3 blocking peptide
KCNIP3 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
calsenilin: a small calcium-binding protein. Member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Modulates K4 voltage-gated potassium channels. May regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Also functions as a calcium-regulated transcriptional repressor, and to interact with presenilins. May play a role in the regulation of PSEN2 proteolytic processing.
Protein type: Transcription factor; Calcium-binding
Chromosomal Location of Human Ortholog: 2q21.1
Cellular Component: cytosol; dendrite; endoplasmic reticulum; Golgi apparatus; nerve terminal; nucleus; plasma membrane; voltage-gated potassium channel complex
Molecular Function: calcium ion binding; DNA binding; potassium channel activity; potassium channel regulator activity; protein binding; transcription corepressor activity; voltage-gated ion channel activity
Biological Process: apoptosis; intracellular protein transport; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; signal transduction; transcription, DNA-dependent
Research Articles on KCNIP3
Similar Products
Product Notes
The KCNIP3 kcnip3 (Catalog #AAA427869) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The KCNIP3 Immunizing Peptide reacts with Human, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SLLGDLGHTP LS-C. It is sometimes possible for the material contained within the vial of "KCNIP3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
