GPSM2 blocking peptide
GPSM2 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Description
GPSM2: Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2. Ubiquitously expressed. Belongs to the GPSM family.
Protein type: G protein regulator, misc.
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: apical part of cell; cell cortex; cytoplasm
Molecular Function: G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; identical protein binding; nucleotide binding; protein binding
Biological Process: establishment of mitotic spindle orientation; G-protein coupled receptor protein signaling pathway; maintenance of centrosome localization; mitotic spindle organization and biogenesis; regulation of catalytic activity
Disease: Chudley-mccullough Syndrome
Research Articles on GPSM2
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Product Notes
The GPSM2 gpsm2 (Catalog #AAA426838) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The GPSM2 Immunizing Peptide reacts with Human, Dog and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-NRLKGKKY KTNSSTK. It is sometimes possible for the material contained within the vial of "GPSM2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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