Rabbit GPSM2 Polyclonal Antibody | anti-GPSM2 antibody

GPSM2 Antibody

Cat. Num. AAA2518737

• Gene Names: GPSM2; LGN; CMCS; PINS; DFNB82
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: GPSM2; Polyclonal Antibody; GPSM2 Antibody; LGN; Pins; anti-GPSM2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Sequence Length: 684

• Applicable Applications for anti-GPSM2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:200-1:2000; IHC: 1:20-1:200
• Immunogen: Fusion protein of GPSM2
• Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles

Testing Data

NCBI and Uniprot Product Information

• NCBI GI #: 164519122
• NCBI GeneID: 29899
• NCBI Accession #: NP_037428.3
• NCBI GenBank Nucleotide #: NM_013296.4
• Molecular Weight: 76,662 Da
• NCBI Official Full Name: G-protein-signaling modulator 2
• NCBI Official Synonym Full Names: G-protein signaling modulator 2
• NCBI Official Symbol: GPSM2
• NCBI Official Synonym Symbols: LGN; CMCS; PINS; DFNB82
• NCBI Protein Information: G-protein-signaling modulator 2; G-protein signalling modulator 2 (AGS3-like, C. elegans); mosaic protein LGN
• UniProt Protein Name: G-protein-signaling modulator 2
• Protein Family: G-protein-signaling modulator
• UniProt Gene Name: GPSM2
• UniProt Synonym Gene Names: LGN
• UniProt Entry Name: GPSM2_HUMAN

NCBI Description

The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).[provided by RefSeq, Jan 2011]

Uniprot Description

GPSM2: Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2. Ubiquitously expressed. Belongs to the GPSM family.

Protein type: G protein regulator, misc.

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: apical part of cell; cytoplasm; cell cortex

Molecular Function: identical protein binding; protein binding; GTPase regulator activity

Biological Process: G-protein coupled receptor protein signaling pathway; establishment of mitotic spindle orientation; regulation of catalytic activity

Disease: Chudley-mccullough Syndrome