WHIP / WRNIP1 Blocking Peptide | WRNIP1 blocking peptide
WHIP / WRNIP1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
Uniprot Description
WRNIP1: a modulator for initiation or restart of DNA polymerase delta-mediated DNA synthesis. Its ATPase activity may sense DNA ends and regulate the extent of polymerase stimulation.
Protein type: EC 3.6.1.3; Helicase
Chromosomal Location of Human Ortholog: 6p25.2
Cellular Component: membrane; nuclear chromosome, telomeric region; nucleus; perinuclear region of cytoplasm
Molecular Function: ATP binding; ATPase activity; DNA binding; identical protein binding; metal ion binding; protein binding
Biological Process: DNA replication; DNA synthesis during DNA repair; regulation of DNA replication initiation
Research Articles on WRNIP1
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Product Notes
The WRNIP1 wrnip1 (Catalog #AAA426783) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The WHIP / WRNIP1 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: EELRGVDFFK QRRC. It is sometimes possible for the material contained within the vial of "WHIP / WRNIP1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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