DTX1 / Deltex-1 Blocking Peptide | DTX1 blocking peptide

DTX1 / Deltex-1 Immunizing Peptide

Cat. Num. AAA426457

• Gene Names: DTX1; hDx-1
• Reactivity: Human, Mouse, Rat, Dog, Cow
• Synonyms: DTX1 / Deltex-1; DTX1 / Deltex-1 Immunizing Peptide; DTX1; deltex homolog 1 (Drosophila); hDx-1; deltex homolog 1; Deltex-1; DTX1 blocking peptide

• Reactivity: Human, Mouse, Rat, Dog, Cow
• Form/Format: 100ug of dried peptide
• Sequence: CHHIENVLKEDAR
• Sequence Length: 620

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 41352718
• NCBI GeneID: 1840
• NCBI Accession #: NP_004407.2
• NCBI GenBank Nucleotide #: NM_004416.2
• Molecular Weight: 67,368 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase DTX1
• NCBI Official Synonym Full Names: deltex 1
• NCBI Official Symbol: DTX1
• NCBI Official Synonym Symbols: hDx-1
• NCBI Protein Information: E3 ubiquitin-protein ligase DTX1
• UniProt Protein Name: E3 ubiquitin-protein ligase DTX1
• Protein Family: Protein DETOXIFICATION
• UniProt Gene Name: DTX1
• UniProt Synonym Gene Names: Deltex1; hDTX1
• UniProt Entry Name: DTX1_HUMAN

NCBI Description

Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

Uniprot Description

DTX1: Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1. Belongs to the Deltex family.

Protein type: Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 12q24.13

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: ligase activity; Notch binding; protein binding; SH3 domain binding; transcription coactivator activity; ubiquitin protein ligase binding; zinc ion binding

Biological Process: cell surface receptor linked signal transduction; glial cell differentiation; negative regulation of neuron differentiation; negative regulation of T cell differentiation; Notch signaling pathway; protein ubiquitination; regulation of Notch signaling pathway; transcription from RNA polymerase II promoter; transcription, DNA-dependent