KCNQ5 blocking peptide

KCNQ5 Immunizing Peptide

Cat. Num. AAA426187

• Gene Names: KCNQ5; Kv7.5
• Reactivity: Human, Mouse, Rat, Pig, Dog
• Synonyms: KCNQ5; KCNQ5 Immunizing Peptide; potassium voltage-gated channel; KQT-like subfamily; member 5; Kv7.5; OTTHUMP00000016729; OTTHUMP00000064152; OTTHUMP00000064153; potassium channel protein; KCNQ5 blocking peptide

• Reactivity: Human, Mouse, Rat, Pig, Dog
• Form/Format: 100ug of dried peptide
• Sequence: C-ESTDALSLPHVKLK
• Sequence Length: 932

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 28373065
• NCBI GeneID: 56479
• NCBI Accession #: NP_062816.2; NP_001153602.1; NP_001153604.1; NP_1153605.1; NP_001153606.1
• NCBI GenBank Nucleotide #: NM_019842.3
• Molecular Weight: 102,365 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily KQT member 5 isoform 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily Q member 5
• NCBI Official Symbol: KCNQ5
• NCBI Official Synonym Symbols: Kv7.5
• NCBI Protein Information: potassium voltage-gated channel subfamily KQT member 5
• UniProt Protein Name: Potassium voltage-gated channel subfamily KQT member 5
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNQ5
• UniProt Entry Name: KCNQ5_HUMAN

NCBI Description

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Description

Kv7.5: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q14

Cellular Component: clathrin coat; plasma membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding; voltage-gated potassium channel activity

Biological Process: protein complex assembly; synaptic transmission