Thra (zebrafish) Blocking Peptide | Thra blocking peptide
Thra (zebrafish) Immunizing Peptide
It is currently untested in blocking applications.
NCBI and Uniprot Product Information
Uniprot Description
Function: High affinity receptor for triiodothyronine
By similarity. In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development. Ref.1 Ref.4
Subunit structure: Interacts with ncoa2. Ref.4
Subcellular location: Nucleus Ref.1.
Tissue specificity: After the mid-blastula transition (MBT), expressed throughout the deep cells, which give rise to the embryo proper. In adults, isoform 2 shows highest expression in the eye and liver. Expressed in adult gonads. Ref.1
Developmental stage: Expressed both maternally and zygotically. Most abundant during early oogenesis during stages I and II, and expression levels drop by oocyte maturation. Expressed at the 1-cell stage and then again after the MBT from the blastula to early gastrula (shield) stages, during which expression levels decrease. Not detected after gastrulation until adults. Ref.1 Ref.4
Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Ref.4The C-terminal extension present in isoform 1 and absent in isoform 2 (the F-domain) regulates transcriptional activity by altering the selectivity of binding to cofactors. Ref.4
Sequence similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain.
Research Articles on Thra
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Product Notes
The Thra thraa (Catalog #AAA426115) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The Thra (zebrafish) Immunizing Peptide reacts with Zebrafish and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-QEGSTGVA AQED. It is sometimes possible for the material contained within the vial of "Thra (zebrafish), Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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