TIP30 / CC3 Blocking Peptide | HTATIP2 blocking peptide

TIP30 / CC3 Immunizing Peptide

Cat. Num. AAA425210

• Gene Names: HTATIP2; CC3; TIP30; SDR44U1
• Reactivity: Human
• Synonyms: TIP30 / CC3; TIP30 / CC3 Immunizing Peptide; HTATIP2; CC3; TIP30; HIV-1 Tat interactive protein 2; 30kDa; Tat-interacting protein (30kD); 30 kD; 30 kDa; FLJ26963; SDR44U1; short chain dehydrogenase/reductase family 44U; member 1; HTATIP2 blocking peptide

• Reactivity: Human
• Form/Format: 100ug of dried peptide
• Sequence: AETEALSKLREDFR-C
• Sequence Length: 276

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 148728166
• NCBI GeneID: 10553
• NCBI Accession #: NP_001091990.1; NP_006401.3; NP_001091991.1; NP_001091992.1; NP_001091993.1
• NCBI GenBank Nucleotide #: NM_001098520.1
• Molecular Weight: 30,131 Da
• NCBI Official Full Name: oxidoreductase HTATIP2 isoform a
• NCBI Official Synonym Full Names: HIV-1 Tat interactive protein 2
• NCBI Official Symbol: HTATIP2
• NCBI Official Synonym Symbols: CC3; TIP30; SDR44U1
• NCBI Protein Information: oxidoreductase HTATIP2
• UniProt Protein Name: Oxidoreductase HTATIP2
• Protein Family: Oxidoreductase
• UniProt Gene Name: HTATIP2
• UniProt Entry Name: HTAI2_HUMAN

Uniprot Description

HTATIP2: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor; Nuclear envelope

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: cytoplasm; membrane; nuclear envelope; nucleoplasm; nucleus

Molecular Function: oxidoreductase activity; protein binding; transcription coactivator activity

Biological Process: angiogenesis; apoptosis; cell differentiation; negative regulation of apoptosis; nuclear import; regulation of angiogenesis; regulation of transcription from RNA polymerase II promoter; viral reproduction