TIP30 / CC3 Blocking Peptide | HTATIP2 blocking peptide
TIP30 / CC3 Immunizing Peptide
NCBI and Uniprot Product Information
Uniprot Description
HTATIP2: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor; Nuclear envelope
Chromosomal Location of Human Ortholog: 11p15.1
Cellular Component: cytoplasm; membrane; nuclear envelope; nucleoplasm; nucleus
Molecular Function: oxidoreductase activity; protein binding; transcription coactivator activity
Biological Process: angiogenesis; apoptosis; cell differentiation; negative regulation of apoptosis; nuclear import; regulation of angiogenesis; regulation of transcription from RNA polymerase II promoter; viral reproduction