DLG4 / PSD95 Blocking Peptide | DLG4 blocking peptide
DLG4 / PSD95 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PSD-95: a membrane associated guanylate kinase (MAGUK) scaffolding protein located in neural postsynaptic densities. Associates with NMDA receptor NR2 subunits via glutamate serine (aspartate/glutamate) valine motifs in the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Its overexpression or depletion changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. Binds tissue-type plasminogen activator (tPA), mediating neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. Interacts through its first two PDZ domains with NMDAR2A, NMDAR2B, NMDAR2C, NMDAR2D, ACCN3, certain splice forms of NMDAR1, KV4.2, CXADR and synGAP. Interacts through its first two PDZ domains with Kv1.1, Kv1.2, Kv1.3, Kv1.4 and HER4. Interacts through its first PDZ domain with GluR6 and Kv1.4. Interacts through its second PDZ domain with the PDZ domain of nNOS or the C-terminus of NOS1AP. May interact with 5-HT(2A). Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with SAPAP1, SAPAP2, SAPAP3, SAPAP4, MAP1A, and BEGAIN. Interacts through its guanylate kinase-like domain with KIF13B. Two alternatively spliced human isoforms have been reported. Palmitoylation of isoform 1 is required for targeting to postsynaptic density.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: basolateral plasma membrane; cell junction; cortical cytoskeleton; cytoplasm; dendrite cytoplasm; dendritic spine; endoplasmic reticulum; excitatory synapse; extrinsic to internal side of plasma membrane; ionotropic glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; synaptic vesicle; voltage-gated potassium channel complex
Molecular Function: acetylcholine receptor binding; beta-1 adrenergic receptor binding; D1 dopamine receptor binding; guanylate kinase activity; ionotropic glutamate receptor binding; kinase binding; ligand-gated ion channel activity; P2Y1 nucleotide receptor binding; PDZ domain binding; protein binding; protein C-terminus binding; protein complex binding; protein phosphatase binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: elevation of cytosolic calcium ion concentration; establishment and/or maintenance of epithelial cell polarity; establishment of protein localization; learning; MAPKKK cascade; negative regulation of receptor internalization; nervous system development; positive regulation of synaptic transmission; protein complex assembly; regulation of long-term neuronal synaptic plasticity; signal transduction; synaptic transmission; synaptic vesicle maturation
Research Articles on DLG4
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Product Notes
The DLG4 dlg4 (Catalog #AAA425178) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The DLG4 / PSD95 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-EEQARKAF DRATK. It is sometimes possible for the material contained within the vial of "DLG4 / PSD95, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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