SORL1 / LR11 (C Terminus) Blocking Peptide | SORL1 blocking peptide
SORL1 / LR11 (C Terminus) Immunizing Peptide
Expected: Human, Rat, Dog, Cow
Expected: Human, Rat, Dog, Cow
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010]
Uniprot Description
Function: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
Subunit structure: Interacts with GGA1 and ROCK2. Ref.9 Ref.11
Subcellular location: Membrane; Single-pass type I membrane protein
Potential.
Tissue specificity: Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to Ref.1, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to Ref.2, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
Post-translational modification: The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.
Miscellaneous: Genetic variations in SORL1 may be associated with increased risk for late onset Alzheimer disease in some populations.
Sequence similarities: Belongs to the VPS10-related sortilin family. SORL1 subfamily.Contains 5 BNR repeats.Contains 1 EGF-like domain.Contains 6 fibronectin type-III domains.Contains 11 LDL-receptor class A domains.Contains 5 LDL-receptor class B repeats.
Research Articles on SORL1
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Product Notes
The SORL1 sorl1 (Catalog #AAA425163) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The SORL1 / LR11 (C Terminus) Immunizing Peptide reacts with Tested: Mouse Expected: Human, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-KDLIRKTD RSYKVK. It is sometimes possible for the material contained within the vial of "SORL1 / LR11 (C Terminus), Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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