PICK1 blocking peptide
PICK1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PICK1: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.
Protein type: Cell development/differentiation; Adaptor/scaffold; Ligand, receptor tyrosine kinase
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: cell junction; cytoplasm; cytoskeleton; Golgi apparatus; neuron projection; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic membrane; synapse
Molecular Function: actin filament binding; ATPase activity; enzyme binding; G-protein-coupled receptor binding; identical protein binding; metal ion binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase C binding; receptor binding
Biological Process: cellular response to glucose starvation; DNA methylation during embryonic development; DNA methylation during gametogenesis; glial cell development; monoamine transport; neuronal ion channel clustering; positive regulation of receptor internalization; protein amino acid phosphorylation; protein kinase C activation; receptor clustering; retrograde vesicle-mediated transport, Golgi to ER
Research Articles on PICK1
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Product Notes
The PICK1 pick1 (Catalog #AAA425049) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The PICK1 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-HYNKLQAD PKQ. It is sometimes possible for the material contained within the vial of "PICK1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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