Goat TGFBR3 Polyclonal Antibody | anti-TGFBR3 antibody
Goat anti-TGFBR3 Antibody
Western Blot: Preliminary experiments gave an approx 38kDa band in Human Placenta, Lymph Node, and Tonsil lysates and in lysates of cell lines Daudi, Jurkat and MOLT4 after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 93.5kDa according to NP_003234.2. The 38kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
Uniprot Description
TGFBR3: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p33-p32
Cellular Component: cell surface; cytoplasm; external side of plasma membrane; extracellular space; integral to plasma membrane; proteinaceous extracellular matrix; receptor complex
Molecular Function: activin binding; coreceptor activity; fibroblast growth factor binding; glycosaminoglycan binding; heparin binding; PDZ domain binding; protein binding; punt binding; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor binding
Biological Process: BMP signaling pathway; cardiac muscle cell proliferation; cell growth; cell migration; epithelial to mesenchymal transition; heart morphogenesis; immune response; liver development; negative regulation of cell motility; negative regulation of epithelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; organ regeneration; palate development; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of protein binding; response to follicle-stimulating hormone stimulus; response to hypoxia; transforming growth factor beta receptor complex assembly; transforming growth factor beta receptor signaling pathway; ventricular cardiac muscle morphogenesis
Research Articles on TGFBR3
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Product Notes
The TGFBR3 tgfbr3 (Catalog #AAA421888) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-TGFBR3 Antibody reacts with Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's TGFBR3 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Preliminary experiments gave an approx 38kDa band in Human Placenta, Lymph Node, and Tonsil lysates and in lysates of cell lines Daudi, Jurkat and MOLT4 after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 93.5kDa according to NP_003234.2. The 38kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the TGFBR3 tgfbr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: TKSIRDDIPS TQGN. It is sometimes possible for the material contained within the vial of "TGFBR3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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