Goat AUTS2 Polyclonal Antibody | anti-AUTS2 antibody
Goat anti-AUTS2 Antibody
Western Blot: Preliminary experiments gave an approx 60kDa band in Human Brain (Cerebral Cortex and Frontal Cortex) lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 139kDa according to NP_056385.1 and of 136kDa according to NP_001120703.1. The 60kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
This gene has been implicated in neurodevelopment and as a candidate gene for numerous neurological disorders, including autism spectrum disorders, intellectual disability, and developmental delay. Mutations in this gene have also been associated with non-neurological disorders, such as acute lymphoblastic leukemia, aging of the skin, early-onset androgenetic alopecia, and certain cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2014]
Uniprot Description
AUTS2: encoded by an autism susceptibility gene. Strongly expressed in brain, skeletal muscle and kidney. Also expressed in placenta, lung and leukocytes. The gene is interrupted by a translocation breakpoint in a pair of autistic twins. Two alternatively-spliced isoforms have been described.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 7q11.22
Cellular Component: nucleus
Molecular Function: chromatin binding
Biological Process: positive regulation of histone H3-K4 methylation; positive regulation of transcription from RNA polymerase II promoter; righting reflex
Disease: Mental Retardation, Autosomal Dominant 26
Research Articles on AUTS2
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Product Notes
The AUTS2 auts2 (Catalog #AAA421875) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-AUTS2 Antibody reacts with Expected from sequence similarity: Human, Mouse, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's AUTS2 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Preliminary experiments gave an approx 60kDa band in Human Brain (Cerebral Cortex and Frontal Cortex) lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 139kDa according to NP_056385.1 and of 136kDa according to NP_001120703.1. The 60kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the AUTS2 auts2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: ERPPSHTLKD IEAR. It is sometimes possible for the material contained within the vial of "AUTS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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