Goat KCNB1/DRK1 Polyclonal Antibody | anti-KCNB1 antibody
Goat anti-KCNB1/DRK1 Antibody
Western Blot: Preliminary experiments gave a 100kDa band and additional stronger bands at approx 50kDa and 38kDa in Human Brain (Cerebellum) and Heart lysates after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the extra bands we observe given the calculated size of 95.9kDa according to NP_004966.1. Both detected extra bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
NCBI and Uniprot Product Information
NCBI Description
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]
Uniprot Description
Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation; Channel, potassium
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: axon; cell junction; dendrite; intracellular; lateral plasma membrane; perikaryon; plasma membrane; postsynaptic membrane; sarcolemma; voltage-gated potassium channel complex
Molecular Function: delayed rectifier potassium channel activity; protein binding; protein heterodimerization activity; small conjugating protein binding
Biological Process: cellular response to nutrient levels; glucose homeostasis; glutamate signaling pathway; negative regulation of insulin secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; protein homooligomerization; regulation of action potential; regulation of insulin secretion; vesicle docking during exocytosis
Disease: Epileptic Encephalopathy, Early Infantile, 26
Research Articles on KCNB1
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Product Notes
The KCNB1 kcnb1 (Catalog #AAA421559) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-KCNB1/DRK1 Antibody reacts with Expected from sequence similarity: Human, Mouse, Dog, Cow, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's KCNB1/DRK1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Preliminary experiments gave a 100kDa band and additional stronger bands at approx 50kDa and 38kDa in Human Brain (Cerebellum) and Heart lysates after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the extra bands we observe given the calculated size of 95.9kDa according to NP_004966.1. Both detected extra bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands). Researchers should empirically determine the suitability of the KCNB1 kcnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: HQYIDADTDD EGQ. It is sometimes possible for the material contained within the vial of "KCNB1/DRK1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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