Goat PITPNM/PITPNM1 Polyclonal Antibody | anti-PITPNM1 antibody
Goat anti-PITPNM/PITPNM1 Antibody
Western Blot: Customer's experiments gave a band at approx 160kDa in lysates of a Mouse Macrophage cell line after 2ug/ml antibody staining (calculated MW of 135kDa according to NP_004901.1). In ICC the customer found staining of vesicular cytoplasm in the same cell line.
NCBI and Uniprot Product Information
NCBI Description
PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]
Uniprot Description
PITPNM1: putatively transfers phosphatidylinositol and phosphatidylcholine between membranes. Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Has higher affinity for the inactive, GDP-bound form of RHOA. Necessary for normal completion of cytokinesis and for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. Interacts with PIK4CA and with Pyk2 via its C-terminus. Phosphorylated on multiple sites by CDC2 at the onset of mitosis. CDC2-phosphorylated forms may interact with PLK1. Interacts with VAPB. Phosphorylated on threonine residues upon treatment with oleic acid.
Protein type: Cell surface
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: cleavage furrow; cytoplasm; endoplasmic reticulum membrane; lipid particle; membrane; midbody
Molecular Function: metal ion binding; phosphatidylinositol transporter activity; protein binding
Biological Process: brain development; lipid metabolic process; phospholipid transport; phototransduction; protein transport
Research Articles on PITPNM1
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Product Notes
The PITPNM1 pitpnm1 (Catalog #AAA420098) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-PITPNM/PITPNM1 Antibody reacts with Tested: Mouse; Expected from sequence similarity: Human, Mouse, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's PITPNM/PITPNM1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC). Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Customer's experiments gave a band at approx 160kDa in lysates of a Mouse Macrophage cell line after 2ug/ml antibody staining (calculated MW of 135kDa according to NP_004901.1). In ICC the customer found staining of vesicular cytoplasm in the same cell line. Researchers should empirically determine the suitability of the PITPNM1 pitpnm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: KARSISLKLD SEE. It is sometimes possible for the material contained within the vial of "PITPNM/PITPNM1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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