Rabbit anti-Human ABCD3 Polyclonal Antibody | anti-ABCD3 antibody

ABCD3 Antibody

Cat. Num. AAA416703

• Gene Names: ABCD3; ZWS2; ABC43; PMP70; PXMP1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: ABCD3; Polyclonal Antibody; ABCD3 Antibody; anti-ABCD3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This Polyclonal antibody is directed against human ABCD3 protein. The product was purified from serum by protein A chromatography. Expect reactivity with human ABCD3. Cross-reactivity with ABCD3 from other sources has not been determined.
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 236

• Applicable Applications for anti-ABCD3 antibody: Western Blot (WB)
• Immunogen: Synthetic peptide derived from human ABCD3.
• Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Western Blot (WB)

Related Product Information for anti-ABCD3 antibody

ABCD3 is a Rabbit polyclonal to ABCD3

NCBI and Uniprot Product Information

• NCBI GI #: 169881286
• NCBI GeneID: 5825
• NCBI Accession #: NP_001116146.1
• NCBI GenBank Nucleotide #: NM_001122674.1
• UniProt Accession #: P28288; Q15271; Q6NUN5; Q96DA3; Q9H529; D3DT46
• Molecular Weight: 75,476 Da
• NCBI Official Full Name: ATP-binding cassette sub-family D member 3 isoform b
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family D (ALD), member 3
• NCBI Official Symbol: ABCD3
• NCBI Official Synonym Symbols: ZWS2; ABC43; PMP70; PXMP1
• NCBI Protein Information: ATP-binding cassette sub-family D member 3; 70 kDa peroxisomal membrane protein; Peroxisomal membrane protein-1 (70kD); peroxisomal membrane protein 1 (70kD, Zellweger syndrome); dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))
• UniProt Protein Name: ATP-binding cassette sub-family D member 3
• Protein Family: ABC transporter D family
• UniProt Gene Name: ABCD3
• UniProt Synonym Gene Names: PMP70; PXMP1; PMP70
• UniProt Entry Name: ABCD3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. Ref.11

Subunit structure: Can form heterodimers with ABCD1/ALD and ABCD2/ALDR. Dimerization is necessary to form an active transporter. Interacts with PEX19. Ref.8 Ref.9 Ref.10

Subcellular location: Peroxisome membrane; Multi-pass membrane protein Ref.10.

Miscellaneous: Mutation in ABCD3 have been found in two individuals affected by Zellweger syndrome. However, the role of ABCD3 in the causation of Zellweger syndrome remains uncertain.

Sequence similarities: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. [View classification]Contains 1 ABC transmembrane type-1 domain.Contains 1 ABC transporter domain.