FGF20 active protein

Recombinant Human FGF20

Cat. Num. AAA4159788

• Gene Names: FGF20; RHDA2; FGF-20
• Purity: >95% as determined by SDS-PAGE
• Synonyms: FGF20; Recombinant Human FGF20; FGF-20; Recombinant Human Fibroblast Growth Factor 20 (FGF20); FGF20 active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 um filtered solution in 10mM MOPS, 10mM ammonium sulphate, 0.2mM DTT and 0.2mM EDTA (pH 7.0).
• Sequence Length: 211

• Bioactivity: Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method.
• Reconstitution: Reconstitute at 10 ug/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Testing Data

Testing Data

Related Product Information for FGF20 active protein

FGF-20 is a heparin binding protein of the FGF family which works to control cell division, differentiation, and function. These proteins are especially prominent during prenatal development and postnatal growth. FGF-20 shares a high degree of homology with FGF-9 and FGF-16. The group of receptors which FGF-20 binds to comprises of FGFR1c, FGFR2c, FGFR3b, FGFR3c and FGFR4. It is shown that FGF-20 is found in a variety of cells, including but limited to, dopaminergic neurons, fibroblasts, keratinocytes and breast epithelium.

NCBI and Uniprot Product Information

• NCBI GI #: 9789947
• NCBI GeneID: 26281
• NCBI Accession #: NP_062825.1
• NCBI GenBank Nucleotide #: NP_062825.1
• UniProt Accession #: Q9NP95
• Molecular Weight: 23.5 kDa
• NCBI Official Full Name: fibroblast growth factor 20
• NCBI Official Synonym Full Names: fibroblast growth factor 20
• NCBI Official Symbol: FGF20
• NCBI Official Synonym Symbols: RHDA2; FGF-20
• NCBI Protein Information: fibroblast growth factor 20
• UniProt Protein Name: Fibroblast growth factor 20
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF20
• UniProt Synonym Gene Names: FGF-20
• UniProt Entry Name: FGF20_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

Uniprot Description

FGF20: Neurotrophic factor that regulates central nervous development and function. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: extracellular region

Molecular Function: 1-phosphatidylinositol-3-kinase activity; growth factor activity; heparan sulfate proteoglycan binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding

Biological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of neuron apoptosis; phosphoinositide-mediated signaling; positive regulation of cell proliferation; regulation of dopamine secretion; regulation of phosphoinositide 3-kinase cascade; signal transduction

Disease: Renal Hypodysplasia/aplasia 2