Western Blot (WB)
Rabbit HES-1 Polyclonal Antibody | anti-HES-1 antibody
Anti-HES-1 Antibody
Western blot analysis: 1:200-1000
Optimal dilutions/concentrations should be determined by the end user.
Western Blot (WB)
Western Blot (WB)
J. Orthop. Res. 25 (2), 152-163 (2007).
NCBI and Uniprot Product Information
NCBI Description
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
Uniprot Description
HES1: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Protein type: Motility/polarity/chemotaxis; Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 3q28-q29
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; histone deacetylase binding; chaperone binding; transcription factor activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; midbrain-hindbrain boundary morphogenesis; hindbrain morphogenesis; radial glial cell differentiation in the forebrain; somatic stem cell maintenance; regulation of fat cell differentiation; regulation of timing of neuron differentiation; cell maturation; positive regulation of JAK-STAT cascade; negative regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; midbrain development; positive regulation of cell proliferation; adenohypophysis development; trochlear nerve development; positive regulation of T cell proliferation; protein complex assembly; oculomotor nerve development; cell adhesion; positive regulation of mitotic cell cycle, embryonic; positive regulation of Notch signaling pathway; positive regulation of BMP signaling pathway; positive regulation of astrocyte differentiation; STAT protein nuclear translocation; positive regulation of DNA binding; nervous system development; smoothened signaling pathway; Notch signaling pathway; cell migration; auditory receptor cell fate determination; thymus development; liver development; endocrine pancreas development; negative regulation of oligodendrocyte differentiation; telencephalon development; lateral inhibition; negative regulation of auditory receptor cell differentiation; neuron morphogenesis during differentiation; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; lung development
Research Articles on HES-1
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Product Notes
The HES-1 hes1 (Catalog #AAA415724) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-HES-1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HES-1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA titer: 1:80,000 Western blot analysis: 1:200-1000 Optimal dilutions/concentrations should be determined by the end user. Researchers should empirically determine the suitability of the HES-1 hes1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HES-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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